军队老年人认知功能障碍和阿尔茨海默病危险因素的流行病学研究
发布时间：2018-11-10 16:59
【摘要】：目的：初步探讨职业电磁辐射暴露及其他危险因素与老年人认知功能障碍的关系 方法：选取总参通讯部北京第一干休所军队离退休老干部为研究对象，设计调查问卷，由经过培训的调查员进行面对面问卷调查，化验检查按统一要求和操作程序进行，在解放军总医院生化科完成。所有数据录入Access数据库，并导入SPSS12.0版统计软件进行分析。根据简易精神状态检查量表得分将研究对象分为认知功能异常组和正常组进行比较，单因素分析计算OR值(95％可信限)和t值；多因素分析采用非条件Logistic逐步回归模型。 结果： 1．社会人口学情况：本研究实际调查273人(男229，女44)，平均68.8±5.8岁，其中已婚者254人(占总体的93.0％)，，脑力劳动者占大多数(97.1％)。 2．单因素分析结果显示吸烟、脑卒中病史和慢性阻塞性肺病病史在两组间差异明显，其OR值(95％可信限)分别为2.61(1.16-5.88)、5.09(2.05-12.68)和2.74(1.15-6.54)。 3．多因素分析结果显示调整了年龄、性别及其他影响因素后，吸烟、饮酒、收缩压水平增高、胆固醇水平增高和脑卒中病史是认知功能损伤的危险因素，OR值(95％可信限)分别为3.87(1.40-10.68)、4.07(1.12-14.79)、1.04(1.01-1.07)、2.04(1.11-3.74)、4.79(1.56-14.68)；电磁暴露的OR值(95％可信限)为0.60(0.24-1.51)。 结论：吸烟、饮酒、脑卒中病史、血压升高和高胆固醇血症是促使认知功能减退的危险因素，未能发现电磁暴露与认知功能改变的关系。
[Abstract]:Objective: to explore the relationship between occupational electromagnetic radiation exposure and other risk factors and cognitive impairment in the elderly. The questionnaire was designed and investigated face to face by trained investigators. The laboratory examination was carried out according to the unified requirements and operation procedures and was completed in the biochemical Department of PLA General Hospital. Input all data into Access database, and import SPSS12.0 version of statistical software for analysis. The subjects were divided into cognitive dysfunction group and normal group according to the scores of simple mental state examination. The OR value (95% confidence limit) and t value were calculated by univariate analysis, and the non-conditional Logistic stepwise regression model was used in multivariate analysis. Results: 1. Social demography: 273 people (229 males, 44 females) were investigated in this study, with an average age of 68.8 卤5.8 years, of which 254 (93.0%) were married. Mental labor accounted for the majority (97.1%). 2. Univariate analysis showed that smoking, stroke history and chronic obstructive pulmonary disease history were significantly different between the two groups, and their OR values (95% confidence limit) were 2.61 (1.16-5.88), respectively. 5.09 (2.05-12.68) and 2.74 (1.15-6.54). 3. The results of multivariate analysis showed that after adjusting for age, sex and other influencing factors, smoking, drinking, systolic blood pressure, cholesterol and stroke history were risk factors of cognitive impairment. The OR values (95% confidence limit) were 3.87 (1.40-10.68), 4.07 (1.12-14.79), 1.04 (1.01-1.07), 2.04 (1.11-3.74), 4.79 (1.56-14.68), respectively. The OR value of electromagnetic exposure (95% confidence limit) was 0.60 (0.24-1.51). Conclusion: smoking, drinking, stroke history, elevated blood pressure and hypercholesterolemia are the risk factors of cognitive dysfunction.
【学位授予单位】：中国人民解放军军医进修学院
【学位级别】：硕士
【学位授予年份】：2004
【分类号】：R82
本文编号：2323036
[Abstract]:Objective: to explore the relationship between occupational electromagnetic radiation exposure and other risk factors and cognitive impairment in the elderly. The questionnaire was designed and investigated face to face by trained investigators. The laboratory examination was carried out according to the unified requirements and operation procedures and was completed in the biochemical Department of PLA General Hospital. Input all data into Access database, and import SPSS12.0 version of statistical software for analysis. The subjects were divided into cognitive dysfunction group and normal group according to the scores of simple mental state examination. The OR value (95% confidence limit) and t value were calculated by univariate analysis, and the non-conditional Logistic stepwise regression model was used in multivariate analysis. Results: 1. Social demography: 273 people (229 males, 44 females) were investigated in this study, with an average age of 68.8 卤5.8 years, of which 254 (93.0%) were married. Mental labor accounted for the majority (97.1%). 2. Univariate analysis showed that smoking, stroke history and chronic obstructive pulmonary disease history were significantly different between the two groups, and their OR values (95% confidence limit) were 2.61 (1.16-5.88), respectively. 5.09 (2.05-12.68) and 2.74 (1.15-6.54). 3. The results of multivariate analysis showed that after adjusting for age, sex and other influencing factors, smoking, drinking, systolic blood pressure, cholesterol and stroke history were risk factors of cognitive impairment. The OR values (95% confidence limit) were 3.87 (1.40-10.68), 4.07 (1.12-14.79), 1.04 (1.01-1.07), 2.04 (1.11-3.74), 4.79 (1.56-14.68), respectively. The OR value of electromagnetic exposure (95% confidence limit) was 0.60 (0.24-1.51). Conclusion: smoking, drinking, stroke history, elevated blood pressure and hypercholesterolemia are the risk factors of cognitive dysfunction.
【学位授予单位】：中国人民解放军军医进修学院
【学位级别】：硕士
【学位授予年份】：2004
【分类号】：R82
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