空气模拟潜水后小鼠的氧化应激状态研究

发布时间：2019-01-16 03:22

【摘要】：目的探讨空气模拟潜水前后小鼠氧化应激状态的变化。方法48只昆明种小鼠用随机数字表法分为常压空气对照组(NA)、常氧高氮组(HN)、高压氧组(HO)、压缩空气暴露后1d组(HA1)、压缩空气暴露后3d组(HA3)以及压缩空气暴露后5d组(HA5);各组暴露于相应压力条件下,每次60min,每天2次,连续3d。相应时间点取血,检测各组丙二醛(MDA)、谷胱甘肽(GSH)、谷胱苷肽鄄S转移酶(GSH鄄Px)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)的变化情况。结果与对照组相比,纯氧组及压缩空气暴露后1d组各指标均显著变化(P0.05,P0.01),且在常氧高氮组与压缩空气暴露后1d组之间差异存
[Abstract]:Objective to investigate the changes of oxidative stress state in mice before and after air simulated diving. Methods 48 Kunming mice were randomly divided into normal air control group (NA),) and hyperbaric oxygen group (HN), hyperbaric oxygen group) 1 day after (HO), compressed air exposure (HA1). Three days after compressed air exposure (HA3) and five days after compressed air exposure (HA5); Each group was exposed to the corresponding pressure for 60 minutes, twice a day for 3 days. The changes of GSH-Px), superoxide dismutase (SOD),) catalase (CAT) (CAT) were detected at the corresponding time points. The changes of malondialdehyde (MDA) (MDA), glutathione (GSH),) glutathione-S transferase (GSH-Px),) were measured. Results compared with the control group, the indexes of pure oxygen group and compressed air exposure group were significantly changed (P0.05, P0.01), and the difference existed between normoxic high nitrogen group and compressed air exposure group 1 day after exposure.
【作者单位】：第二军医大学海军医学系航海医学教研室第二军医大学海军医学系航海医学教研室第二军医大学海军医学系航海医学教研室第二军医大学海军医学系航海医学教研室第二军医大学海军医学系航海医学教研室第二军医大学海军医学系航海医学教研室
【分类号】：R84

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