进驻高原官兵跟骨定量超声测定及尿DPD改变观察

发布时间：2019-02-19 16:17

【摘要】：目的探讨平原地区官兵进驻高原地区后骨代谢变化。方法采用UBIS 30 0 0型定量超声仪 ,对 1 1 5名官兵跟骨进行定量超声测定 ,同时用化学发光免疫法测定尿脱氧吡啶酚 (DPD)排泄浓度。将进驻高原地区 2个月后的测定结果与返回平原 2个月后的测定结果进行对比分析。结果进驻高原地区官兵跟骨超声振幅衰减 (BUA)、超声声速 (SOS)和刚度 (STI)各年龄段均较返回平原组显著降低 (P 0 .0 1 )。尿DPD排泄浓度高原组 2 0岁以下和 2 1～ 30岁年龄段分别为 (2 1 0 .79± 78.6 9)nmol·L 1和 (4 1 6 .995± 33.80 )nmol·L 1高于平原组的 (1 34.5 1± 98.96 )nmol·L 1和 (1 2 1 .2 0± 6 6 .87)nmol·L 1(P 0 .0 1 ) ,30～ 4 0岁和 4 0岁以上年龄段也有差异 (P 0 .0 5 )。结论平原地区官兵进驻高原 2个月后 ,因受高原缺氧等因素的影响 ,可导致骨代谢异常 ,骨吸收增加。提示 ,进驻高原地区前应及时进行预防治疗 ,避免骨质疏松的发生。
[Abstract]:Objective to investigate the changes of bone metabolism after officers and soldiers were stationed in plateau area in plain area. Methods the calcaneus of 115 officers and soldiers were measured by quantitative ultrasound with UBIS 3000 type quantitative ultrasound instrument. The excretion concentration of deoxypyridinol (DPD) in urine was determined by chemiluminescence immunoassay. The results after 2 months in the plateau were compared with those after 2 months in the plain. Results the ultrasonic amplitude attenuation of calcaneus (BUA), ultrasonic velocity (SOS) and stiffness (STI) (STI) were significantly lower than those in the plain group (P 0.01). The urinary DPD excretion concentration in the high altitude group was 210.79 卤78.69) nmol L 1 and (416.995 卤33.80) nmol L 1) higher than that in the plain group, respectively (210.79 卤78.69) nmol L 1 and 21.30 years old). 1 卤98.96) nmol L 1 and (121.20 卤66.87) nmol L 1, P < 0.01). There were also differences between 30 ~ 40 years old and over 40 years old (P 0.05). Conclusion two months after entering the plateau, the officers and soldiers in the plain area were affected by hypoxia and other factors, which resulted in abnormal bone metabolism and increased bone resorption. The results suggest that prevention and treatment should be carried out in time to avoid osteoporosis.
【作者单位】：兰州军区兰州总医院骨科研究所兰州军区兰州总医院骨科研究所兰州军区兰州总医院骨科研究所兰州军区兰州总医院骨科研究所
【基金】：”十五”全军重大课题项目 (No.0 .1Z0 18)
【分类号】：R82

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