复合益生菌制剂对长航核潜艇员体液免疫功能的调节

发布时间：2019-03-06 08:03

【摘要】：目的观察及评价复合益生菌制剂对长航核潜艇员体液免疫功能的调节作用。方法受试艇员分为用药组和未用药组 ,并以另一艘未出航的核潜艇艇员 (未出航组 )为空白对照。观察长航前后各组体液免疫指标血清含量变化。结果 (1 )未用药组航后IgG含量高于航前 ,IgM高于航前和未出航组 (P 0 .0 5 )。用药组航后IgA含量高于未用药组 ,而IgM低于未用药组 (P 0 .0 5 ) ,IgA亦高于航前和未出航组 (P 0 .0 5 ) ,IgG仅高于航前 (P 0 .0 5 )。 (2 )未用药组航后补体C3及B因子水平较航前和未出航组降低 (P 0 .0 5 ,P 0 .0 1 ) ,C4 则较航前升高 (P 0 .0 5 )。用药组航后与未用药组比较 ,C4 水平降低 ,而C3及B因子水平增高 (P 0 .0 5 ) ,但B因子低于航前 (P 0 .0 5 )。 (3)未用药组IL - 4水平航后较航前和未出航组升高 (P 0 .0 5 ) ,IL - 6较航前及未出航组升高 (P 0 .0 1 )。用药组航后IL - 4及IL - 6水平均明显低于未用药组 (P 0 .0 5 ) ,但IL - 6仍高于航前 (P 0 .0 5 )。 (4 )未用药组CRP及CIC航后的水平均较航前和未出航组升高(P 0 .0 5 )。用药组航后CRP及CIC低于未用药组 (P 0 .0 5 )。结论复合益生菌制剂可从多方面对长航核潜艇员的体液免疫功能进行调节 ,主要体现为阻抑核潜艇长航训练所致体液免
[Abstract]:Objective to observe and evaluate the effect of compound probiotics on humoral immune function of long-distance nuclear submariners. Methods the test crew were divided into two groups: the medication group and the non-medication group, and another nuclear submarine crew (not out of flight group) was used as the blank control group. The changes of serum humoral immune indexes were observed before and after Changhang. Results (1) the content of IgG in the untreated group was higher than that in the pre-flight group, and the level of IgM in the untreated group was higher than that in the pre-and non-sailing group (P 0.05). The content of IgA in the treatment group was higher than that in the non-medication group, while the IgM was lower than that in the non-medication group (P 0.05), IgA) (P 0.05), IgG was only higher than that in the pre-voyage group and the non-departure group (P 0.05), but it was lower in the control group than that in the control group (P < 0.05). (2) the levels of complement C3 and factor B in the untreated group were lower than those in the pre-and non-sailing group (P 0.05, P 0.01), while the C _ 4 level was higher than that in the pre-flight group (P < 0.05), but that of C _ 4 in the control group was higher than that in the control group (P < 0.05). Compared with the control group, the level of C4 decreased, while the level of C3 and factor B increased (P 0.05), but the level of factor B was lower in the treated group than that in the control group (P 0.05). (3) the level of IL-4 in the untreated group was higher than that in the pre-flight and no-departure group (P 0.05), IL-6), which was higher than that in the pre-flight and no-departure group (P < 0.01), and that in the control group was significantly higher than that in the control group (P < 0.01). The levels of IL-4 and IL-6 in the treatment group were significantly lower than those in the control group (P < 0.05), but the level of IL-6 was still higher than that before the voyage (P 0.05). (4) the levels of CRP and CIC in the untreated group were higher than those in the pre-and non-sailing group (P 0.05). The levels of CRP and CIC in the treatment group were lower than those in the control group (P 0.05). Conclusion the compound probiotics preparation can regulate the humoral immune function of the nuclear submariners in many aspects, which is mainly embodied in the inhibition of liquid immunity caused by the long voyage training institute of nuclear submarines.
【作者单位】：海军第四0一医院海军第四0一医院海军第四0一医院海军第四0一医院海军第四0一医院海军第四0一医院
【基金】：全军“九·五”医学规划课题项目 (No .96D0 0 5 )
【分类号】：R84

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