军队老年男性代谢综合征与血清IL-10、hs-CRP的关系
发布时间：2019-05-13 23:39
【摘要】： 目的观察军队老年男性代谢综合征(metabolic syndrome，MS)患者血清白细胞介素10(Interleukin-10，IL-10)、高敏C反应蛋白(high sensitive C reactive protein，hs-CRP)水平的变化，探讨炎症标志物IL-10、hs-CRP与代谢综合征的关系。 方法对2006年11月至12月间在163医院门诊体检的408名军队退休男性老干部测定腰围(waist circumference，WC)、体重、身高、血压、空腹血糖(fasting plasma glucose，FPG)、血脂水平，并计算体重指数(body mass Index，BMI)，分析其代谢紊乱的特征。据国际糖尿病联盟(IDF)颁布的MS诊断标准，入选58例老年MS患者和29例年龄相匹配的对照者，测量其血压、腰围(WC)、体重、身高、体重指数(BMI)、血脂、空腹血糖(FPG)、空腹血胰岛素(fastinginsulin，FINS)、抵抗指数(homeostasis model assessment of Insulin Resistance，HOMA-IR)，血清IL-10浓度用酶联免疫吸附剂法测定(enzyme linked immunosorbent assay，，ELISA)，血清hs-CRP水平用乳胶增强免疫比浊法检测。 结果1．408名军队退休男性老干部中超重或肥胖者237例(占58.1％)，中心性肥胖者(腰围≥90cm)243例(占51.6％)，高血压病者287例(占70.3％)，高血糖患者135例(占33.1％)，血脂紊乱者(高TG或／和低HDL-C)95例(占23-3％)，MS患者135例(占33.1％)；可见2种代谢紊乱组中以高血压+超重或肥胖组合(占58.9％)最多，3种代谢紊乱组中以高血压+超重或肥胖+血脂紊乱组合(占57.5％)最多；有3种以上MS相关疾病者占该人群总数的近30％。2．MS组血清IL-10浓度显著低于对照组(P＜0.05)；按HOMA-IR分组发现：胰岛素抵抗亚组(HOMA-IR≥4.3 1)IL-10水平显著低于非胰岛素抵抗亚组(HOMA-IR＜4.3 1)(P=0.000)。3．MS患者血清hs-CRP浓度显著高于对照者(P＜0.05)；按HOMA-IR、WC分组发现：非胰岛素抵抗亚组(HOMA-IR＜4.31)hs-CRP水平低于胰岛素抵抗亚组(HOMA-IR≥4.31) (P＞0.05)；中心性肥胖亚组(WC≥90cm)血清hs-CRP浓度显著高于非中心性肥胖亚组(WC＜90cm) (P=0.008)；MS患者血清hs-CRP水平随着MS组分数目的增加而升高。4．Pearson相关分析显示在MS组中，IL-10与HOMA-IR(r=-0.797，P=0.000)、FINS(r=-0.731，P=0.000)、FPG(r=-0.303，P=0.021)之间存在负相关。在MS组中，hs-CRP与年龄(r=0.270，P=0.040)、BMI(r=0.346，P=0.008)之间存在正相关。5．Stepwise逐步回归分析显示在MS组中，腰围、HOMA—IR、FINS可能为IL-10的影响因素；在MS组中，年龄、BMI可能为hs-CRP的影响因素； 结论1．408名军队退休男性老干部中MS相关疾病患者所占比例较高。2．老年男性MS患者血清IL-10浓度显著降低血清hs-CRP显著升高，提示存在低度慢性炎症。3．老年男性MS，患者血清IL-10浓度降低，可能与高胰岛素血症、胰岛素抵抗密切相关。4．老年男性MS患者血清hs-CRP水平随着MS组分数目的增加而升高，并可能与年龄、BMI相关。
[Abstract]:Objective to observe the changes of serum IL-10 (Interleukin-10,IL-10) and Gao Min C-reactive protein (high sensitive C reactive protein,hs-CRP (high sensitive C reactive protein,hs-CRP) in elderly men with metabolic syndrome (metabolic syndrome,MS), and to explore the inflammatory marker IL-10,. Relationship between hs-CRP and metabolic syndrome. Methods from November to December 2006, the waist circumference (waist circumference,WC), weight, height, blood pressure, fasting blood glucose (fasting plasma glucose,FPG) and blood lipid levels were measured in 408retired male military cadres who were examined in the outpatient clinic of 163Hospital. The body mass index (body mass Index,BMI) was calculated and the characteristics of metabolic disorder were analyzed. According to the MS diagnostic standard promulgated by the International Diabetes Union (IDF), 58 elderly MS patients and 29 age-matched controls were selected to measure their blood pressure, waist circumference (WC), weight, height, body mass index (BMI),) blood lipid. Fasting blood glucose (FPG), fasting blood insulin (fastinginsulin,FINS), resistance index (homeostasis model assessment of Insulin Resistance,HOMA-IR), serum IL-10 concentration was determined by enzyme-linked immunosorbent assay (enzyme linked immunosorbent assay,ELISA), The level of serum hs-CRP was detected by latex enhanced immune turbidimetry. Results of the 1.408 retired male cadres, 237 (58.1%) were overweight or obese, 243( 51.6%) were central obesity (waist circumference 90 cm), and 287 (70.3%) were hypertension. There were 135 patients with hyperglycemia (33.1%) and 95 patients with dyslipidemia (high TG or / and low HDL-C) (23%) with), MS (33.1%). It can be seen that hypertension overweight or obesity group (58.9%) is the most common metabolic disorder group, and hypertension overweight or obese dyslipidemia group (57.5%) is the most common metabolic disorder group. The serum IL-10 concentration in the near 30%.2.MS group, which accounted for more than three MS-related diseases, was significantly lower than that in the control group (P < 0.05). According to HOMA-IR group, the level of IL-10 in insulin resistance subgroup (HOMA-IR 鈮
本文编号：2476268
[Abstract]:Objective to observe the changes of serum IL-10 (Interleukin-10,IL-10) and Gao Min C-reactive protein (high sensitive C reactive protein,hs-CRP (high sensitive C reactive protein,hs-CRP) in elderly men with metabolic syndrome (metabolic syndrome,MS), and to explore the inflammatory marker IL-10,. Relationship between hs-CRP and metabolic syndrome. Methods from November to December 2006, the waist circumference (waist circumference,WC), weight, height, blood pressure, fasting blood glucose (fasting plasma glucose,FPG) and blood lipid levels were measured in 408retired male military cadres who were examined in the outpatient clinic of 163Hospital. The body mass index (body mass Index,BMI) was calculated and the characteristics of metabolic disorder were analyzed. According to the MS diagnostic standard promulgated by the International Diabetes Union (IDF), 58 elderly MS patients and 29 age-matched controls were selected to measure their blood pressure, waist circumference (WC), weight, height, body mass index (BMI),) blood lipid. Fasting blood glucose (FPG), fasting blood insulin (fastinginsulin,FINS), resistance index (homeostasis model assessment of Insulin Resistance,HOMA-IR), serum IL-10 concentration was determined by enzyme-linked immunosorbent assay (enzyme linked immunosorbent assay,ELISA), The level of serum hs-CRP was detected by latex enhanced immune turbidimetry. Results of the 1.408 retired male cadres, 237 (58.1%) were overweight or obese, 243( 51.6%) were central obesity (waist circumference 90 cm), and 287 (70.3%) were hypertension. There were 135 patients with hyperglycemia (33.1%) and 95 patients with dyslipidemia (high TG or / and low HDL-C) (23%) with), MS (33.1%). It can be seen that hypertension overweight or obesity group (58.9%) is the most common metabolic disorder group, and hypertension overweight or obese dyslipidemia group (57.5%) is the most common metabolic disorder group. The serum IL-10 concentration in the near 30%.2.MS group, which accounted for more than three MS-related diseases, was significantly lower than that in the control group (P < 0.05). According to HOMA-IR group, the level of IL-10 in insulin resistance subgroup (HOMA-IR 鈮
本文编号：2476268
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