军队老年人阿尔茨海默病危险因素的病例对照研究

发布时间：2019-06-04 11:17

【摘要】：目的 探讨军队老年人阿尔茨海默病(AD)的危险因素,初步分析早年电磁暴露与AD的关系。方法 采用病例对照研究。选择解放军总医院近年来确诊的62例军队AD患者为病例组,在同一医院住院治疗的离退休老干部中按照年龄段分层抽样(按1:2比例)选取124例对照。调查方式为电话访谈。结果 单因素分析结果显示,病例组社会活动情况明显少于对照组,早年电磁暴露、体育锻炼情况、负性生活事件、慢性阻塞性肺病病史、既往癌症病史、痴呆家族史在两组间差异有显著性。在调整相关影响因素后,负性生活事件、痴呆家族史、社会活动量的OR值(95％CI)分别为3.27(1.53～6.97)、5.78(1.39～24.10)和0.81(0.72～0.92),早年电磁暴露的OR值(95％CI)为2.49(0.96～6.45),而既往癌症病史和吸烟似与AD呈负相关。结论 负性生活事件、痴呆家族史、社会活动减少是AD的独立危险因素,早年电磁暴露是其可能的危险因素;吸烟和既往癌症病史与AD呈负相关的原因可能与该老年人群的“生存偏性”有关。
[Abstract]:Objective to investigate the risk factors of Alzheimer's disease (AD) in military elderly and to analyze the relationship between early electromagnetic exposure and AD. Methods A case-control study was conducted. 62 military AD patients diagnosed in the PLA General Hospital in recent years were selected as the case group. 124 controls were selected according to the age group (according to the proportion of 1:2) among the retired cadres hospitalized in the same hospital. The way of investigation is telephone interview. Results the results of univariate analysis showed that the social activities in the case group were significantly lower than those in the control group, early electromagnetic exposure, physical exercise, negative life events, chronic obstructive pulmonary disease history, and previous cancer history. There was significant difference in the family history of dementia between the two groups. After adjusting for the related influencing factors, the OR values (95%CI) of negative life events, family history of dementia and social activity were 3.27 (1.53 鈮，

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