天然小分子化合物调节小胶质细胞预防阿尔茨海默病免疫失衡（英文）
发布时间：2020-12-04 13:31
阿尔茨海默病(Alzheimer’s disease,AD)是最常见的中枢神经系统退行性疾病,其发病机制复杂,至今仍未完全阐明.最近的研究表明,小胶质细胞过度激活、炎症因子的过度产生与AD的发病密切相关.小胶质细胞受体及下游通路的异常调节可导致AD患者及AD实验动物的免疫失衡.天然小分子化合物通过激活小胶质细胞的抑炎受体,抑制促炎受体或调节Aβ清除受体,可逆转免疫失衡.本文综述了小胶质细胞在AD慢性炎症中的作用机制,并总结天然小分子化合物通过调节小胶质细胞受体及其下游通路在AD免疫稳态中的有益作用.
【文章来源】：生物化学与生物物理进展. 2020年08期 第712-728页 北大核心
【文章页数】：17 页
【文章目录】：
1 The inflammatory response is a key factor in the pathogenesis of Alzheimer’s disease
2 Improper regulation of microglial receptors and their downstream pathways impair immune homeostasis in AD
2.1 Increase release of inflammatory cytokines via activation of microglial pro-inflammatory receptors and their downstream pathways in AD
2.2 Decrease expression of anti-inflammatory receptors in microglia aggravate the imbalance of inflammatory cytokines in AD
2.3 Improper regulation of the Aβclearance receptor in microglia promote the progress of AD
3 Natural small-molecule compounds regulate the pathological process of Alzheimer’s disease by maintaining immune homeostasis
3.1 Natural small-molecule compounds inhibit the activation of microglial pro-inflammatory receptors and their downstream pathways in AD
3.2 Natural small-molecule compounds activate microglial anti-inflammatory receptors and its downstream pathways in AD
3.3 Natural small-molecule compounds show its benefit effects through regulate the receptors involved in Aβclearance in AD
4 Summary and prospect
【参考文献】：
期刊论文
[1]Nature brings new avenues to the therapy of central nervous system diseases——an overview of possible treatments derived from natural products[J]. Junchi Zhang,Yang He,Xiangrui Jiang,Hualiang Jiang,Jingshan Shen. Science China(Life Sciences). 2019(10)
[2]Herbal decoctosome is a novel form of medicine[J]. Xiaoyun Li,Zhu Liang,Jianchao Du,Zhiqing Wang,Song Mei,Zhiqing Li,Yan Zhao,DANDan Zhao,Yiming Ma,Jun Ye,Jiantao Xu,Yu Zhao,Jiahui Chang,Yuhao Qin,Lanlan Yu,Chenxuan Wang,Chengyu Jiang. Science China(Life Sciences). 2019(03)
[3]模式识别受体激活状态对小胶质细胞p38-MAPK磷酸化水平的影响[J]. 郑翰轩,张郃. 生物技术进展. 2018(02)
[4]Celastrol specifically inhibits the activation of NLRP3 inflammasome[J]. Xuesong Sang,Yihui Chen,Wei Chen,Jing Xie,Guangxun Meng,Jin Zhong,Taisheng Li,Ailing Lu. Science China(Life Sciences). 2018(03)
[5]川芎嗪通过抑制RAGE-ERK1/2-p38-NFκB信号通路及活性氧生成改善阿尔茨海默病大鼠脑组织炎性[J]. 刘长安,朱洁,蔡标,黄金玲. 中国药学杂志. 2014(13)
[6]远志总皂苷对AD模型大鼠学习记忆及海马nAChRα7亚基的影响[J]. 赵大鹏,李晓峰,陈树沙,景玮,邢婕,穆俊霞,李新毅. 中国神经免疫学和神经病学杂志. 2012(05)
[7]红景天苷对Aβ1～40所致阿尔茨海默病模型大鼠认知功能改善作用及机制探讨[J]. 张佳,宋立刚,孔卫娜,邵铁梅,温昕,刘培,柴锡庆. 中国中药杂志. 2012(14)
[8]大豆异黄酮对阿尔茨海默病大鼠海马RAGE介导的信号转导通路的影响[J]. 刘长安,汪远金,那莎,朱洁,蔡标. 中国中西医结合杂志. 2012(06)
[9]灯盏乙素对痴呆大鼠脑组织乙酰胆碱尼古丁受体蛋白及mRNA表达的作用[J]. 郭莉莉,王永林,黄勇,官志忠. 中国中西医结合杂志. 2011(06)
硕士论文
[1]Trem2激活促进抗炎和自噬改善阿尔茨海默病行为学的研究[D]. 辜敏.重庆医科大学 2016
[2]吴茱萸碱对阿尔茨海默病模型大鼠HMGB1/TLR4/NF-κB信号通路的研究[D]. 孙文蕾.河北医科大学 2015
[3]蛇床子素对阿尔茨海默病模型大鼠认知障碍的神经保护作用及其机制研究[D]. 郑为娜.河北医科大学 2015
本文编号：2897694
【文章来源】：生物化学与生物物理进展. 2020年08期 第712-728页 北大核心
【文章页数】：17 页
【文章目录】：
1 The inflammatory response is a key factor in the pathogenesis of Alzheimer’s disease
2 Improper regulation of microglial receptors and their downstream pathways impair immune homeostasis in AD
2.1 Increase release of inflammatory cytokines via activation of microglial pro-inflammatory receptors and their downstream pathways in AD
2.2 Decrease expression of anti-inflammatory receptors in microglia aggravate the imbalance of inflammatory cytokines in AD
2.3 Improper regulation of the Aβclearance receptor in microglia promote the progress of AD
3 Natural small-molecule compounds regulate the pathological process of Alzheimer’s disease by maintaining immune homeostasis
3.1 Natural small-molecule compounds inhibit the activation of microglial pro-inflammatory receptors and their downstream pathways in AD
3.2 Natural small-molecule compounds activate microglial anti-inflammatory receptors and its downstream pathways in AD
3.3 Natural small-molecule compounds show its benefit effects through regulate the receptors involved in Aβclearance in AD
4 Summary and prospect
【参考文献】：
期刊论文
[1]Nature brings new avenues to the therapy of central nervous system diseases——an overview of possible treatments derived from natural products[J]. Junchi Zhang,Yang He,Xiangrui Jiang,Hualiang Jiang,Jingshan Shen. Science China(Life Sciences). 2019(10)
[2]Herbal decoctosome is a novel form of medicine[J]. Xiaoyun Li,Zhu Liang,Jianchao Du,Zhiqing Wang,Song Mei,Zhiqing Li,Yan Zhao,DANDan Zhao,Yiming Ma,Jun Ye,Jiantao Xu,Yu Zhao,Jiahui Chang,Yuhao Qin,Lanlan Yu,Chenxuan Wang,Chengyu Jiang. Science China(Life Sciences). 2019(03)
[3]模式识别受体激活状态对小胶质细胞p38-MAPK磷酸化水平的影响[J]. 郑翰轩,张郃. 生物技术进展. 2018(02)
[4]Celastrol specifically inhibits the activation of NLRP3 inflammasome[J]. Xuesong Sang,Yihui Chen,Wei Chen,Jing Xie,Guangxun Meng,Jin Zhong,Taisheng Li,Ailing Lu. Science China(Life Sciences). 2018(03)
[5]川芎嗪通过抑制RAGE-ERK1/2-p38-NFκB信号通路及活性氧生成改善阿尔茨海默病大鼠脑组织炎性[J]. 刘长安,朱洁,蔡标,黄金玲. 中国药学杂志. 2014(13)
[6]远志总皂苷对AD模型大鼠学习记忆及海马nAChRα7亚基的影响[J]. 赵大鹏,李晓峰,陈树沙,景玮,邢婕,穆俊霞,李新毅. 中国神经免疫学和神经病学杂志. 2012(05)
[7]红景天苷对Aβ1～40所致阿尔茨海默病模型大鼠认知功能改善作用及机制探讨[J]. 张佳,宋立刚,孔卫娜,邵铁梅,温昕,刘培,柴锡庆. 中国中药杂志. 2012(14)
[8]大豆异黄酮对阿尔茨海默病大鼠海马RAGE介导的信号转导通路的影响[J]. 刘长安,汪远金,那莎,朱洁,蔡标. 中国中西医结合杂志. 2012(06)
[9]灯盏乙素对痴呆大鼠脑组织乙酰胆碱尼古丁受体蛋白及mRNA表达的作用[J]. 郭莉莉,王永林,黄勇,官志忠. 中国中西医结合杂志. 2011(06)
硕士论文
[1]Trem2激活促进抗炎和自噬改善阿尔茨海默病行为学的研究[D]. 辜敏.重庆医科大学 2016
[2]吴茱萸碱对阿尔茨海默病模型大鼠HMGB1/TLR4/NF-κB信号通路的研究[D]. 孙文蕾.河北医科大学 2015
[3]蛇床子素对阿尔茨海默病模型大鼠认知障碍的神经保护作用及其机制研究[D]. 郑为娜.河北医科大学 2015
本文编号：2897694
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