具有抗炎活性的中药对脂肪酸合酶的抑制作用（英文）

发布时间：2020-12-23 08:25

　　随着肥胖及其相关疾病的患病率不断上升,肥胖并发的慢性炎症已成为一个不容忽视的公共卫生问题,迫切需要针对肥胖相关慢性炎症新的治疗方案和干预策略.脂肪酸合酶(fatty acid synthase,FAS)是一种多功能复合酶,是治疗肥胖、糖尿病、非酒精性脂肪肝、炎症和癌症的潜在靶点.持续的炎症反应是潜在的危险因素.一些关键的炎症标志物与肥胖密切相关,其中特别是FAS抑制剂的研究受到越来越多的关注.在我国,中药已广泛被应用于炎症的治疗,其中有多种中药对FAS表现出强抑制作用.本文综述了中药FAS抑制剂的结构和活性特点,对于研发中药FAS抑制剂治疗炎症提供了依据. 

【文章来源】：生物化学与生物物理进展. 2020年08期 北大核心

【文章页数】：9 页

【文章目录】：
1 FAS and FAS inhibitors
    1.1 FAS is related to human diseases
    1.2 Classical FAS inhibitors
    1.3 Natural FAS inhibitors derived from TCMs
2 The involvement of FAS in inflammation
    2.1 FAS and inflammation are involved in many diseases
    2.2 FFA,the end product of FAS,induces inflammation
    2.3 FAS mediates inflammatory response through lipid membrane
    2.4 Inflammatory signaling pathways involved in FAS
        2.4.1 NF-κB
        2.4.2 JAK-STAT
        2.4.3 TLR
3 TCMs with anti-inflammtion abilities
4 Anti-inflammation function of FASinhibitors derived from TCM:facts and perspectives


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