中西医结合治疗肺癌恶性胸腔积液临床观察

发布时间：2018-01-04 22:22

本文关键词：中西医结合治疗肺癌恶性胸腔积液临床观察　出处：《辽宁中医药大学》2009年硕士论文　论文类型：学位论文

【摘要】： 目的:通过将48例肺癌恶性胸腔积液患者进行分组对照研究治疗,来观察中西医结合方法治疗肺癌恶性胸腔积液的临床疗效,了解中西医结合治疗方法在提高患者生存质量和降低化疗药物的毒副作用等方面的优势。方法:遵循随机对照原则将48例患者分成治疗组和对照组各24例,采用胸腔内置入引流管的方法,将胸腔积液放净后,对照组腔内注入顺铂及乌体林斯注射液,治疗组加用葶苈大枣泻肺汤合苓桂术甘汤加减口服的治疗方法。结果: 1.治疗组完全缓解(CR)11例、部分缓解(PR)8例、缓解率79.17%;对照组完全缓解(CR)7例、部分缓解(PR)5例、缓解率50.55%。两组经统计学x。检验计算得出P=0.035,小于0.05,有显著性差异; 2.KPS评分与治疗前比较,治疗组7例患者升高20分、10例患者升高10分、升高率70.83%;对照组3例患者升高20分、7例患者升高10分、升高率41.67%。两组经统计学χ~2检验计算得出P=0.042,小于0.05,有显著性差异; 3.毒副反应情况,治疗组1例出现恶心、1例出现白细胞计数低于正常值下限、1例出现寒战发热,阳性率12.50%;对照组2例出现恶心呕吐、3例出现白细胞计数低于正常值下限、3例出现寒战发热、1例出现寒战发热合并恶心呕吐,阳性率37.5096。两组经统计学χ~2检验计算得出P=0.046,小于＜0.05,有显著性差异。结论: 1.胸穿放积液加腔内注入顺铂及乌体林斯结合中药葶苈大枣泻肺汤合苓桂术甘汤加减的中西医结合方法,对比胸腔内注入顺铂和乌体林斯的单纯西医方法,在治疗肺癌恶性胸腔积液中能有效控制积液的增长速度,较好的达到对症治疗的目的。 2.以上方法在治疗肺癌恶性胸腔积液中能更好地提高了患者的生存质量、减轻患者痛苦,同时能在一定程度上减轻化疗药物对机体的毒副作用。
[Abstract]:Objective: through 48 cases of lung cancer patients with malignant pleural effusion were divided into control study of treatment, to observe the clinical curative effect of traditional Chinese and Western medicine treatment of lung cancer with malignant pleural effusion, to understand the combination therapy in improving the quality of life of patients and reduce the side effects of chemotherapy drugs and other advantages.
Methods: according to randomized controlled principles of the 48 patients were divided into treatment group and control group with 24 cases in each group, the chest built into the drainage tube, the pleural effusion on the net, the control group injected cisplatin and Wutilinsi injection, treatment group treated with Tingli Dazao xiefei Decoction Lingguizhugan Decoction taken orally..
Result:
1., in the treatment group, there were 11 cases of complete remission (CR), 8 cases of partial remission (PR), and 79.17% of the remission rate. 7 cases of complete remission (CR) and 5 cases of partial remission (PR) in the control group, and two 50.55%. in the remission rate were calculated by statistical X. test, and P=0.035 was less than 0.05.
2.KPS score compared with before treatment, 7 patients in the treatment group increased 20 points, 10 patients increased 10 points, the rise rate was 70.83%; the 3 patients in the control group increased 20 points, 7 patients increased 10 points, the rate of increase was 41.67%.. Two group by statistical Chi ~2 test calculated P=0.042, less than 0.05, there was a significant difference.
3. adverse reactions, the treatment group of 1 cases of nausea, 1 cases of white blood cell count below the normal limit, chills and fever occurred in 1 cases, the positive rate was 12.50%; the control group of 2 cases of nausea and vomiting, 3 cases of white blood cell count below the normal limit, 3 cases of chills and fever, chills and fever occurred in 1 cases with nausea and vomiting, the positive rate of 37.5096. of two groups after statistical x ~2 test to calculate P=0.046, less than < 0.05, the difference was statistically significant.
Conclusion:
Methods 1. thoracic puncture effusion and intracavitary injection of cisplatin and placed Utilins combined with traditional Chinese medicine Tingli Dazao xiefei Decoction Lingguizhugan Decoction of traditional Chinese medicine and Western medicine, the western medicine method of cisplatin and Utilins intrapleural injection of contrast, can effectively control the growth rate of effusion in the treatment of malignant pleural effusion of lung cancer, can achieve the purpose of symptomatic treatment.
More than 2. of the above methods can improve the quality of life and relieve the pain of patients with malignant pleural effusion of lung cancer, and at the same time, to a certain extent, reduce the side effects of chemotherapy drugs on the body.

【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2009
【分类号】：R734.2

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