强直性脊柱炎骨量丢失的中西医结合诊治进展

发布时间：2018-02-07 12:01

本文关键词： 中医中药强直性脊柱炎骨丢失中西医结合　出处：《中国骨质疏松杂志》2017年01期 　论文类型：期刊论文

【摘要】：强直性脊柱炎是一种慢性进行性骨关节病,主要影响中轴骨骼并导致显着的疼痛和残疾。多见于青少年,主要侵犯骶髂关节、髋关节和脊柱,并且可伴有关节外表现。早期表现为肌腱、韧带附着点的炎症,进而出现关节骨质破坏,软骨内、韧带纤维化及异位骨化,造成脊柱关节强直改变,最终导致残废。在我国强直性脊柱炎的发病率约为0.3%,是临床最常见的风湿病之一,发病高峰年龄为15~30岁,男性的患病率比女性高2~3倍,且男性平均发病年龄要早于女性平均发病年龄。骨质疏松作为强直性脊柱炎最常见的一种并发症,以全身性骨病,以骨各种成分等比例减少而导致骨脆性增加、易发生骨折为特征,其发生率为50%~92%,并且有35%的强直性脊柱炎患者可发生因骨质疏松而导致椎体压缩性骨折。目前,强直性脊柱炎的治疗主要以西医为主,存在明显的局限性,中医中药可以充分弥补其不足,中西医结合多途径多靶点阻断骨量丢失,可望能为强直性脊柱炎的治疗拓展新思路,提供新方法。
[Abstract]:Ankylosing spondylitis (ankylosing spondylitis) is a chronic progressive osteoarthropathy that mainly affects the axial bones and results in significant pain and disability. And it may be accompanied by extraarticular manifestations. The early manifestations are inflammation of tendon and ligamentous attachment points, and then the destruction of articular bone, cartilage, ligament fibrosis and ectopic ossification, which result in the change of ankylosis of spine joint. The incidence of ankylosing spondylitis in China is about 0.3 percent, which is one of the most common rheumatic diseases in clinical practice. The peak age of the disease is 1530 years old, and the prevalence rate of men is 2 to 3 times higher than that of women. As the most common complication of ankylosing spondylitis, osteoporosis is the most common complication of ankylosing spondylitis. The incidence of fracture is 50%, and 35% of the patients with ankylosing spondylitis can have vertebral compression fracture due to osteoporosis. At present, the treatment of ankylosing spondylitis is mainly western medicine, and there are obvious limitations in the treatment of ankylosing spondylitis. Traditional Chinese medicine can fully make up for its deficiency, and the combination of traditional Chinese and western medicine can block the loss of bone mass in many ways and targets, which is expected to expand new ideas and provide new methods for the treatment of ankylosing spondylitis (ankylosing spondylitis).
【作者单位】：浙江中医药大学;浙江省人民医院风湿免疫科;
【分类号】：R593.23

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