电针联合小剂量氯氮平治疗难治性精神分裂症的疗效观察

发布时间：2018-02-07 14:42

本文关键词： 难治性精神分裂症电针疗法氯氮平阳性与阴性症状量表副反应量表　出处：《针刺研究》2010年02期 　论文类型：期刊论文

【摘要】：目的:评价电针联合小剂量氯氮平治疗难治性精神分裂症的有效性和安全性。方法:将难治性精神分裂症患者随机分为西药组和针药结合组各40例。西药组患者均采用口服氯氮平治疗;针药结合组患者选百会及太阳穴电针治疗,同时口服小剂量氯氮平。比较两组患者治疗前后阳性与阴性症状量表(PAN-SS)、副反应量表(TESS)评分及临床疗效。结果:两组治疗后PANSS均下降,且两组比较差异无统计学意义(P0.05)。治疗后针药结合组TESS评分结果显著低于西药组(P0.01)。西药组愈显率35.0%(14/40),有效率77.5%(31/40),针药结合组愈显率32.5%(13/40),有效率72.5%(29/40),两组比较差异无统计学意义(P0.05)。结论:两组方法治疗难治性精神分裂症疗效相当,而针药结合组不良反应更轻,提示电针配合小剂量氯氮平是治疗难治性精神分裂症的较好方法。
[Abstract]:Objective: to evaluate the efficacy and safety of electroacupuncture combined with low dose clozapine in the treatment of refractory schizophrenia. Methods: patients with refractory schizophrenia were randomly divided into western medicine group (40 cases) and acupuncture combined group (40 cases). All patients were treated with oral clozapine. The patients in the acupuncture and medicine combination group were treated with Baihui and temple electroacupuncture, and were treated with low dose clozapine. The scores of PAN-SSN, side effects and clinical efficacy were compared between the two groups before and after treatment. Results: after treatment, PANSS decreased in both groups. There was no significant difference between the two groups (P 0.05). After treatment, the TESS score in the combined acupuncture and medicine group was significantly lower than that in the western medicine group. There was no significant difference between the two groups in the effective rate of 37.5% / 40%, the effective rate of 32.5% / 40%, the effective rate of 72.5% / 40%. There was no significant difference between the two groups. Conclusion: the efficacy of the two groups in the treatment of refractory schizophrenia is similar. However, the adverse effects of acupuncture combined with medicine were lighter, suggesting that electroacupuncture combined with low dose clozapine was a better method for the treatment of refractory schizophrenia.
【作者单位】：江西省宜春市第三人民医院精神科;宜春市医药协会办公室;
【分类号】：R749.3;R246

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