HANS仪刺激百会穴影响异丙酚效应的PET研究

发布时间：2018-02-09 04:43

本文关键词： 正电子发射计算机断层显像葡萄糖代谢 HANS仪百会穴异丙酚　出处：《中国疼痛医学杂志》2007年01期 　论文类型：期刊论文

【摘要】：目的:应用正电子发射计算机断层显像,观察韩氏穴位神经刺激仪(简称HANS仪)刺激百会穴对异丙酚麻醉脑葡萄糖代谢的影响。方法:18只实验用小型猪随机分为3组,HANS组(n=6),基础麻醉后,采用HANS仪电刺激百会穴,以2/100Hz变频电刺激25min,注射显像剂18F-FDG32min后PET扫描;异丙酚组(n=6),基础麻醉后输注异丙酚6mg/kg·h,15min后用1min静注显像剂,继续输注异丙酚6mg/kg·h,32min后PET扫描;针药复合组(n=6),基础麻醉后,HANS仪以2/100Hz变频电刺激百会穴25min,停电针,输注异丙酚6mg/kg·h,15min后用1min静注显像剂,异丙酚6mg/kg·h继续输注32min后PET扫描。结果:HANS仪2/100Hz变频刺激百会穴使异丙酚麻醉相应脑区葡萄糖代谢明显下降(P0.01)。结论:电刺激百会穴具有加强异丙酚麻醉效应的作用,其作用机制之一是显著降低了脑代谢。
[Abstract]:Objective: to apply positron emission computed tomography (PET). To observe the effect of HANS stimulation on cerebral glucose metabolism in propofol anesthesia. Methods Twenty six miniature pigs were randomly divided into 3 groups. After basic anesthesia, Baihui points were stimulated by HANS instrument. The patients in the propofol group were injected with propofol (6 mg / kg 路h ~ (-1)) for 15 minutes and then injected with the imaging agent (1 / 100 Hz) for 25 min, and the PET scan was performed after the injection of propofol (6 mg / kg 路h ~ (32) min) after injection of propofol (6 mg / kg 路h ~ (32) min). After basic anesthesia, the rats were stimulated with 2 / 100 Hz frequency conversion electric stimulation at Baihui point for 25 min. The power cut needle was injected with propofol 6 mg / kg 路h ~ (-1) for 15 min, and then the imaging agent was injected intravenously for 1 min. PET scan was performed after infusion of propofol 6 mg / kg 路h for 32 minutes. Results the stimulation of Baihui point with 2 / 100 Hz frequency conversion of propofol anesthesia significantly decreased glucose metabolism in the corresponding cerebral area of propofol anesthesia. Conclusion: electric stimulation of Baihui point can enhance the anesthetic effect of propofol. One of its mechanisms is to significantly reduce brain metabolism.
【作者单位】：广东省人民医院麻醉科广东省人民医院麻醉科广东省人民医院PET中心广东省人民医院麻醉科广东省人民医院麻醉科河南省新郑市人民医院麻醉科广东省人民医院麻醉科广东省人民医院麻醉科广东省人民医院PET中心
【基金】：2003年广东省中医药局资助项目(编号103103)
【分类号】：R245

【参考文献】