中西医结合治疗儿童激素耐药性肾病综合征临床观察

发布时间：2018-04-16 13:02

本文选题：肾病综合征 + 激素耐药　；参考：《四川中医》2007年01期

【摘要】：目的:观察中西医结合治疗小儿激素耐药性肾病综合征的疗效并探讨其作用机制。方法:将53例激素耐药的肾病综合征患儿分为中西药治疗组36例和西药对照组17例,西药组采用激素、免疫抑制剂等治疗;中西药组在西药组治疗的基础上加服中药肾病合剂治疗。结果:中西药组完全缓解率6个月为75.4%,1年为80.6%;西药组完全缓解率分别为41.2%、51.9%,两组有显著性差异。且治疗组免疫球蛋白IgG、IgA较治疗前明显提高,与健康组比较无显著性差异(P0.05)。结论:中药肾病合剂可提高西药治疗儿童耐药性肾病综合征的疗效,其作用机理可能与其免疫调节作用及提高激素治疗的敏感性有关。
[Abstract]:Objective: to observe the therapeutic effect of integrated traditional Chinese and western medicine on steroid-resistant nephrotic syndrome in children and explore its mechanism.Methods: 53 children with steroid-resistant nephrotic syndrome were divided into Chinese and western medicine treatment group (36 cases) and western medicine control group (17 cases). The western medicine group was treated with hormone and immunosuppressant.Chinese and western medicine group on the basis of western medicine treatment plus traditional Chinese medicine nephropathy mixture treatment.Results: the complete remission rate in the Chinese and western medicine group was 75.4 in 6 months and 80.6 in one year, and the complete remission rate in the western medicine group was 41.2 and 51.9, respectively, with significant difference between the two groups.The immunoglobulin IgG IgA in the treatment group was significantly higher than that in the control group, and there was no significant difference between the treatment group and the healthy group (P 0.05).Conclusion: traditional Chinese medicine nephropathy mixture can improve the efficacy of western medicine in the treatment of children with drug-resistant nephrotic syndrome, and its mechanism may be related to its immunomodulating effect and enhancing the sensitivity of hormone therapy.
【作者单位】：天津中医药大学第一附属医院天津中医药大学第一附属医院天津中医药大学第一附属医院
【分类号】：R726.9

【共引文献】