中西医结合治疗抑郁症的疗效及对患者血清单胺类神经递质的影响

发布时间：2018-04-30 03:10

  本文选题：盐酸文拉法辛 + 自拟中药方　； 参考：《中华中医药学刊》2017年05期

【摘要】：目的:探讨盐酸文拉法辛联合自拟中药方治疗抑郁症的疗效及对患者血清单胺类神经递质的影响。方法:收治的抑郁症患者200例,按照随机数字表法分为治疗组100例和对照组100例。对照组口服盐酸文拉法辛,治疗组在对照组基础上服用自拟中药方。两组疗程均为8周。结果:治疗组总有效率(92.00%)高于对照组(79.00%),且有统计学差异(P0.05);治疗组患者治疗后HAMD评分低于对照组,ADL评分高于对照组,且有统计学差异(P0.05);治疗组患者治疗后血清DA、NE、5-HT水平高于对照组,且有统计学差异(P0.05);治疗组患者治疗后心烦易怒、精神抑郁、情绪不宁积分低于对照组,且有统计学差异(P0.05);治疗组不良反应发生率(10.00%)低于对照组(36.00%),且有统计学差异(P0.05)。结论:盐酸文拉法辛联合自拟中药方治疗抑郁症的疗效显著,调节患者血清单胺类神经递质的代谢水平,具有重要意义。
[Abstract]:Aim: to investigate the effect of venlafaxine hydrochloride combined with traditional Chinese medicine on the treatment of depression and its effect on monoamine neurotransmitters. Methods: 200 patients with depression were randomly divided into treatment group (n = 100) and control group (n = 100). The control group took venlafaxine hydrochloride orally, and the treatment group took the Chinese medicine prescription on the basis of the control group. The course of treatment was 8 weeks in both groups. Results: the total effective rate of the treatment group (92.00) was higher than that of the control group (79.00%), and the difference was statistically significant (P 0.05), the HAMD score of the treatment group was lower than that of the control group (P 0.05), and the difference was significant (P 0.05), and the serum DANE-5-HT level of the treatment group was higher than that of the control group. After treatment, the scores of irritability, depression and emotional restlessness in the treatment group were lower than those in the control group (P 0.05), and the incidence of adverse reactions in the treatment group was 10.00%, which was significantly lower than that in the control group (P 0.05). Conclusion: the efficacy of venlafaxine hydrochloride combined with traditional Chinese medicine in the treatment of depression is remarkable, and it is of great significance to regulate the metabolism level of monoamine neurotransmitters in patients' serum.
【作者单位】： 浙江省立同德医院精神科;
【分类号】：R749.4
，

本文编号：1822798