PCOS患者早期自然流产与子宫内膜雌孕激素受体的关系及中西医结合治疗

发布时间：2018-05-23 13:51

本文选题：多囊卵巢综合征 + 早期流产　；参考：《中国计划生育学杂志》2011年05期

【摘要】：目的:探讨多囊卵巢综合征(PCOS)患者早期自然流产与子宫内膜雌激素受体(ER)、孕激素受体(PR)的关系以及中西医结合治疗的可行性。方法:选择PCOS不孕患者62例为观察组,同期输卵管性不孕患者30例为对照组。两组患者均于月经干净3～7d时在宫腔镜下取子宫内膜标本,行免疫组织化学检查,观察ER和PR在子宫内膜腺体和间质细胞的表达强度,比较两组的差异。再于术后对观察组对象给予达英-35联合中药天癸方连续治疗3个月经周期,停药后第1次月经干净3~7d在宫腔镜引导下取子宫内膜标本,观察治疗前后ER、PR表达强度的变化。结果:ER、PR在子宫内膜腺体和间质中的表达观察组较对照组明显减弱(P0.05);经中西医结合治疗3个周期后,观察组患者子宫内膜腺体和间质中的ER、PR表达强度均明显提高(P0.05)。结论:PCOS患者子宫内膜ER、PR减少可能是其自然流产的重要原因,中西医结合治疗能有效提高PCOS患者子宫内膜ER、PR水平。
[Abstract]:Objective: to investigate the relationship between early spontaneous abortion and endometrial estrogen receptor (ER) and progesterone receptor (PRP) in patients with polycystic ovary syndrome (PCOS). Methods: 62 cases of PCOS infertility were selected as observation group and 30 cases of oviduct infertility as control group. The samples of endometrium were collected under hysteroscopy and the expression of ER and PR in endometrial glands and stromal cells were observed by immunohistochemistry. The difference between the two groups was compared. After operation, the patients in the observation group were treated with Daxin-35 combined with Tiangui recipe for 3 consecutive menstrual cycles. The endometrial specimens were collected under hysteroscopic guidance for 3 days after the first menstruation and the changes of ERPR expression before and after treatment were observed. Results the expression of ERPR in endometrial glands and stroma in the observation group was significantly lower than that in the control group, and the expression of ERPR in the endometrial glands and stroma of the observation group was significantly increased after three cycles of treatment with the combination of traditional Chinese and western medicine (TCM-WM), and the expression intensity of ERPR in the endometrial glands and stroma of the observation group was significantly higher than that of the control group. Conclusion the decrease of endometrial ERPR may be an important cause of spontaneous abortion in patients with PCOS, and the combination of traditional Chinese medicine and western medicine can effectively improve the level of ERPR in endometrium of PCOS patients.
【作者单位】：山东省桓台县妇幼保健院;
【分类号】：R714.21

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