中西医治疗围绝经期抑郁症的临床研究进展

发布时间：2018-07-13 14:36

【摘要】：目的:对治疗围绝经期抑郁症的各种中西医方法做一总结,旨在中西合璧,发挥各自优势,共同提高临床疗效。方法:应用计算机检索相关期刊论文、中文科技期刊数据库、万方中华医学会期刊数据库,以"围绝经期抑郁症+更年期抑郁症+更年期忧郁症"为首次检索词,以不同治疗方法为二次检索词,检索年限:1999年1月—2010年12月。电子检索后经人工筛查,排除科普文献、文献综述、各数据库重复录入的文献。结果:最终搜集到162篇文献,阅读全文,选取较高质量文献对其做一总结。结论:①中医治疗围绝经期抑郁症的方法有中药、针刺、艾灸、推拿、走罐等,目前,对于中药治疗本病的研究起步早,研究多,而针灸方面较少,仅有18篇文献。②西医治疗本病主要使用雌激素和抗抑郁药,临床多联合用药。③心理、运动干预所起的具体作用及成效,还缺乏数据论证。单因素干预因受到伦理学影响,很难进行随机对照研究。④研究的诊断标准过于单一,缺少针对"围绝经期抑郁症"的专有标准;疗效标准除了参照HAMD评分或减分率,还应关注患者血液激素水平,症状改善及生活质量。⑤缺少长期疗效及复发率的统计,各种干预措施的远期疗效不确定,有待进一步完善。总之,中西医综合疗法治疗围绝经期抑郁症疗效显著,副作用小,临床应积极推广,但研究设计还有待优化。
[Abstract]:Objective: to summarize the methods of treating peri-menopausal depression in order to improve the clinical efficacy. Methods: the full text database of Chinese periodicals, the database of Chinese sci-tech periodicals and the database of Chinese Medical Association journals were searched by computer. The first key words were "menopausal depression and menopausal depression". With different treatment methods as the second search term, the retrieval time: January 1999-December 2010. After electronic retrieval, scientific literature, literature review and repeated input documents were excluded by manual screening. Results: 162 articles were collected, the full text was read, and the higher quality literature was selected to summarize them. Conclusion the traditional Chinese medicine treatment of peri-menopausal depression includes traditional Chinese medicine, acupuncture, moxibustion, massage, cupping, etc. At present, the research on traditional Chinese medicine for treating this disease is early, there are more studies, but acupuncture is less. There were only 18 references (.2) in which estrogen and antidepressant were mainly used in the treatment of this disease. The effect and effect of exercise intervention were not proved. Due to the influence of ethics, it is very difficult to conduct randomized controlled study (4). The diagnostic criteria are too single and lack of specific criteria for "peri-menopausal depression". We should also pay attention to the statistics of blood hormone level, symptom improvement and quality of life (QOL). 5. The long-term effect of various intervention measures is uncertain and needs to be further improved. In a word, comprehensive therapy of traditional Chinese and western medicine is effective in the treatment of peri-menopausal depression with small side effects, and should be actively popularized in clinical practice, but the research and design still need to be optimized.
【作者单位】：广州中医药大学第二临床医学院;广东省中医院针灸科;
【基金】：国家自然科学基金(30772828) 广东省科技厅科技计划项目(2008B030301206)
【分类号】：R749.4

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