中西医结合治疗对儿童过敏性紫癜肾损害的预防作用

发布时间：2018-07-13 15:02

【摘要】：目的观察中西医结合治疗儿童过敏性紫癜(HSP)的临床疗效及对肾损害的预防作用。方法将120例患儿随机分为2组。对照组60例,采用西医常规治疗;中西医结合治疗组60例,在对照组基础上应用三黄清血饮治疗。同时选择30名健康儿童作为健康组。观察治疗前后症状、体征,尿常规,血浆内皮素-1(ET-1)、尿β2-微球蛋白(β2-MG)、尿白蛋白(Alb)、尿免疫球蛋白G(IgG)变化及治疗后的复发情况。结果治疗组治愈率、总有效率分别为80.0%(48/60)、98.3%(59/60);对照组分别为61.7%(37/60)、88.3%(53/60),两组比较差异有统计学意义(P0.05);治疗组治愈患儿临床症状消失时间短于对照组,差异有统计学意义(P0.01);治疗组治疗1个月后血浆ET-1、尿β2-MG、尿Alb、尿IgG指标明显改善,均低于本组治疗前及对照组同期水平,差异有统计学意义(P0.01,P0.05),与健康组比较,差异无统计学意义(P0.05)。治疗组1年复发率为13.3%,对照组为30.0%,两组比较差异有统计学意义(P0.05)。结论中西医结合治疗儿童HSP不仅明显减轻临床症状,缩短病程,降低复发率,而且能够有效地预防儿童HSP肾损害。
[Abstract]:Objective to observe the clinical effect of integrated traditional Chinese and western medicine in the treatment of Henoch-Schonlein purpura (HSP) in children and its preventive effect on renal damage. Methods 120 children were randomly divided into two groups. The control group (n = 60) was treated with routine western medicine, while the control group (n = 60) was treated with Sanhuang Qingxue Yin on the basis of the control group. At the same time, 30 healthy children were selected as healthy group. The changes of symptoms, signs, urine routine, plasma endothelin-1 (ET-1), urinary 尾 2-microglobulin (尾 2-MG), urinary albumin (Alb), urine immunoglobulin G (Alb),) and recurrence after treatment were observed. Results the cure rate of the treatment group was 80.0% (48 / 60) and the total effective rate was 98.3% (59 / 60) respectively, while the control group was 61.7% (37 / 60) or 88.3% (53 / 60), the difference was statistically significant (P0.05). After one month of treatment, plasma ET-1, urinary 尾 2-MG, urinary Alb and urinary IgG were significantly improved in the treatment group, which were lower than those before treatment and in the control group (P 0.01 P 0.05), but there was no significant difference between the treatment group and the healthy group (P0.05). The recurrence rate in the treatment group was 13.3 and in the control group was 30.0.The difference between the two groups was statistically significant (P0.05). Conclusion the combination of traditional Chinese and western medicine can not only reduce the clinical symptoms, shorten the course of disease and reduce the recurrence rate, but also effectively prevent the renal damage of children with HSP.
【作者单位】：河北医科大学第二医院;河北省血液中心;
【基金】：河北省科技厅科研课题(No.052761607)
【分类号】：R725.5;R726.9

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