中西医结合治疗哮喘随机对照试验的系统评价

发布时间：2018-12-08 09:41

【摘要】：目的:评估中西医结合治疗支气管哮喘的临床疗效。方法:检索PubMed(1988-2008)、CBMdisc(1978-2008)、CNKI(1980-2008)、VIP(1989-2008),纳入治疗组采用中西医结合疗法,对照组采用西药对照防治支气管哮喘的随机对照试验。纳入试验的方法学质量由两位评价员独立评价,采用RevMan4.2.10软件作meta分析。结果:共纳入26篇随机对照试验,全部研究方法学质量都被评为C级。Meta分析显示,总有效率合并效应值(OR=4.62,CI95%[3.40,6.29],P0.00001),FEV1合并效应值(WMD=0.29,CI95%[0.22,0.35],P0.00001),FEV1%合并效应值(WMD=3.57,CI95%[2.84,4.30],P0.00001),FVC合并效应值(WMD=0.32,CI95%[0.21,0.43],P0.00001),没有发现严重不良反应报道。结论:中西医结合治疗支气管哮喘较单纯西医治疗有更好的疗效,由于纳入研究均存在偏倚的高度可能性,尚需要更多高质量的随机对照试验来证明。
[Abstract]:Objective: to evaluate the clinical effect of integrated traditional Chinese and western medicine on bronchial asthma. Methods: PubMed (1988-2008), CBMdisc (1978-2008), CNKI (1980-2008), VIP (1989-2008) was searched. The treatment group was treated with integrated traditional Chinese and western medicine and the control group was treated with western medicine. The quality of methodology included in the experiment was independently evaluated by two evaluators, and meta analysis was performed with RevMan4.2.10 software. Results: totally 26 randomized controlled trials were conducted, all of which were evaluated as C grade. Meta analysis showed that the total effective rate combined effect value (OR=4.62,CI95% [3.40 卤6.29], P0.00001), FEV1 combined effect value (WMD=0.29,). CI95% [0.22 卤0.35], P0.00001), FEV1% combined effect value (WMD=3.57,CI95% [2.84 卤4.30], P0.00001), FVC combination effect value (WMD=0.32,CI95% [0.21 卤0.43], P0.00001), No serious adverse reactions were reported. Conclusion: combination of traditional Chinese and western medicine is more effective than western medicine in the treatment of bronchial asthma. Because of the high possibility of bias in all the studies, more high quality randomized controlled trials are needed to prove it.
【作者单位】：成都中医药大学;四川大学华西临床医学院;
【分类号】：R259

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