温电针合西药治疗重症肌无力及其对患者血清IL-4的影响

发布时间：2018-12-27 12:20

【摘要】：目的:观察温电针治疗重症肌无力的疗效并探讨其作用机制。方法:将60例患者随机分为针药组和药物组各30例。针药组采用温电针治疗,穴取膻中、石门、关元、中脘、阳陵泉等为主,配合口服西药吡啶斯的明(每日总量90～240 mg)、强的松(每日总量30～60 mg);药物组单纯口服西药吡啶斯的明(每日总量240～480 mg)、强的松(每日总量60～100 mg)。观察2组临床疗效并测定患者治疗前后血清白细胞介素-4(IL-4)的水平。结果:针药组总有效率为93.3%,优于药物组的70.0%(P0.01);2组患者治疗后血清IL-4均有显著下降(P0.01),但针药组的下降程度显著优于药物组(P0.05)。结论:温电针配合西药治疗重症肌无力疗效显著,其可能机制之一是调节IL-4等细胞因子的分泌,使机体异常的免疫应答过程得到纠正,最终抑制自身抗体的产生。
[Abstract]:Objective: to observe the therapeutic effect of warm electroacupuncture on myasthenia gravis and explore its mechanism. Methods: 60 patients were randomly divided into acupuncture group (30 cases) and drug group (30 cases). Acupuncture and medicine group was treated with warm electroacupuncture. The acupoints were collected from Tanzhong, Shimen, Guanyuan, Zhongwan, Yanglingquan, etc., combined with oral administration of western medicine pyridine (total amount of 90 ~ 240 mg), prednisone per day) (total amount of 3060 mg); per day). The drug group took pyridamine alone (total 240 mg), per day) prednisone (total 60,100 mg). Per day) To observe the clinical effect of the two groups and to determine the level of serum interleukin-4 (IL-4) before and after treatment. Results: the total effective rate of acupuncture and medicine group was 93. 3%, which was better than that of drug group (70. 0%) (P0.01). Serum IL-4 decreased significantly in both groups after treatment (P0.01), but the degree of decrease in acupuncture and medicine group was significantly higher than that in drug group (P0.05). Conclusion: the therapeutic effect of warm electroacupuncture combined with western medicine on myasthenia gravis is remarkable. One of its possible mechanisms is to regulate the secretion of cytokines such as IL-4, correct the abnormal immune response, and ultimately inhibit the production of autoantibodies.
【作者单位】：深圳市福田区中医院康复针灸推拿科深圳市福田区中医院康复针灸推拿科深圳市福田区中医院康复针灸推拿科
【分类号】：R246.6;R746.1

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