女性生殖道人乳头状瘤病毒感染及其基因分型与宫颈癌的关系

发布时间：2018-02-03 18:06

  本文关键词： 宫颈癌 宫颈癌前病变 人乳头状瘤病毒 基因分型　出处：《中国病原生物学杂志》2017年12期 　论文类型：期刊论文

【摘要】：目的分析女性生殖道人乳头状瘤病毒(HPV)感染及其基因分型与宫颈癌的关系。方法纳入宫颈癌及宫颈癌前病变患者共150例,其中宫颈癌患者63例(宫颈癌组),宫颈癌前病变患者87例(癌前病变组),另选宫颈炎患者50例作为对照组;分析各组患者HPV感染情况,并进行HPV基因分型检测。结果 200例宫颈疾病患者HPV总阳性率为72.0%(144/200),其中宫颈癌组和癌前病变组HPV阳性率分别为100.0%和67.8%,均显著高于对照组(44.0%)(P0.05),且宫颈癌组HPV阳性率明显高于癌前病变组(P0.05);宫颈癌患者主要感染HPV16、18、33和58,CINⅠ患者主要感染HPV6、11、16、33、52和59,CINⅡ患者主要感染HPV6、11、16、31、33、52和58,CINⅢ患者主要感染HPV16、18、31、33、51和58,对照组患者主要感染HPV6、11、33、43、52、58、66及68;宫颈癌组和癌前病变组高危型HPV阳性率(100.0%、77.3%)均显著高于对照组(42.6%)(P0.05),且宫颈癌组高危型HPV阳性百分比高于癌前病变组(P0.05);宫颈癌组、癌前病变组及对照组单一型HPV感染率分别为100.0%、81.4%和40.9%,多重型HPV感染率分别为0、18.6%和59.1%;HPV感染及高危型HPV感染均与宫颈癌的发生呈正相关(P0.05)。结论宫颈癌的发生与高危型HPV感染密切相关,HPV基因分型检测对宫颈癌前病变及宫颈癌的筛查、诊断及预防具有重要意义。
[Abstract]:Objective to analyze the relationship between human papillomavirus (HPV) infection in female genital tract and cervical cancer. Methods 150 patients with cervical cancer and cervical precancerous lesions were included. There were 63 patients with cervical carcinoma (cervical cancer group), 87 patients with cervical precancerous lesion (precancerous lesion group) and 50 patients with cervicitis as control group. Results the total positive rate of HPV in 200 patients with cervical diseases was 72.0 / 144 / 200). The positive rates of HPV in cervical cancer group and precancerous lesion group were 100.0% and 67.8 respectively, which were significantly higher than those in control group (P 0.05). The positive rate of HPV in cervical cancer group was significantly higher than that in precancerous lesion group (P 0.05). Patients with cervical cancer were mainly infected with HPV16CINI and HPV61116163C3M52 and 59 CINII patients were mainly infected with HPV6. Patients with CIN 鈪，

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