增强T1WI直方图在胶质母细胞瘤和脑单发转移瘤鉴别诊断中的应用

发布时间：2018-02-28 14:00

本文关键词： 胶质母细胞瘤脑肿瘤肿瘤转移磁共振成像病理学外科诊断鉴别　出处：《中国医学影像学杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的胶质母细胞瘤和转移瘤是颅内常见的恶性肿瘤,两者的鉴别对于临床治疗决策的制订具有重要意义。本文探讨增强T1WI直方图在胶质母细胞瘤和单发转移瘤鉴别诊断中的应用价值。资料与方法回顾性分析2012年1月-2015年12月于梅州市人民医院行术前MRI检查,并手术或活检病理证实的脑肿瘤患者68例。其中胶质母细胞瘤34例,脑转移瘤34例。术前行常规MRI扫描。采用Image J软件手动于增强T1WI的肿瘤最大层面勾画实质强化部分,分别计算其相应的平均值、最大值、最小值、标准差、峰度值、偏度值。结果脑单发转移瘤实质强化部分的峰度值(1.260±1.271)大于胶质母细胞瘤(0.071±0.667),差异有统计学意义(P0.05)。以峰度值0.736为临界值,绘制受试者工作特性曲线。曲线下面积为0.792(95%CI:0.676~0.881),鉴别胶质母细胞瘤和单发转移瘤的敏感度为76.47%、特异度为88.24%、阳性预测值为80.65%、阴性预测值为78.38%。结论肿瘤实质强化部分的增强T1WI直方图参数峰度值可用于鉴别胶质母细胞瘤和脑单发转移瘤,为鉴别这2种病变提供可靠的客观依据。
[Abstract]:The purpose of glioblastoma and metastasis is a common intracranial malignant tumor, the differential between the two has important significance for clinical decision making in patients. This paper discusses the enhancement of T1WI histogram in glioblastoma cells and metastatic tumor value in differential diagnosis. Materials and methods a retrospective analysis of January 2012 December -2015 MRI check in Meizhou People's Hospital preoperative, 68 patients with brain tumor and biopsy or surgical pathology cases. 34 cases of glioma, 34 cases of brain metastases. Preoperative conventional MRI scan. The manual to enhance tumor maximum level outline of the essence of T1WI strengthening by Image J software, calculate the corresponding average value, maximum respectively. Value, minimum value, standard deviation, kurtosis, skewness. The results of solitary brain metastasis parenchyma enhancement part of the kurtosis (1.260 + 1.271) than glioblastoma (0.071 + 0.667), with statistical difference Significance (P0.05). The kurtosis value 0.736 as the critical value, receiveroperating characteristic curve. The area under the curve was 0.792 (95%CI:0.676~0.881), identification of glioblastoma cells and metastatic tumor sensitivity was 76.47%, specificity was 88.24%, the positive predictive value was 80.65%, the negative predictive value was 78.38%. conclusion enhancement part of the enhanced T1WI histogram parameters kurtosis can be used for the identification of glioblastoma and solitary brain metastasis, provide a reliable objective basis for the identification of these 2 diseases.

【作者单位】：广东省梅州市人民医院放射科;
【分类号】：R445.2;R739.41

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