肺癌患者血清中21种细胞因子的表达水平及其临床意义

发布时间：2018-03-03 00:23

本文选题：肺癌　切入点：细胞因子　出处：《中国肿瘤生物治疗杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的:检测肺癌患者血清中21种细胞因子[干扰素诱导的T细胞趋化因子(IFN-inducible T cellαchemoattractant,ITAC)、GM-CSF、Fractalkine、IFN-γ、IL-10、巨噬细胞炎性蛋白-3α(macrophage inflammatory protein-3α,MIP-3α)]、IL-12(p70)、IL-13、IL-17A、IL-1β、IL-2、IL-4、IL-21、IL-23、IL-5、IL-6、IL-7、IL-8、MIP-1α、MIP-1β和TNF-α的表达情况并分析其意义。方法:收集2015年3月至6月的山西省肿瘤医院40例肺癌患者;采用液相芯片技术检测30名健康人和40例初诊肺癌患者治疗前血清中21种细胞因子的表达水平,分析其与肺癌临床特征之间的关系及表达存在明显差异细胞因子间的相关性。结果:肺癌患者血清中11种细胞因子[(GM-CSF、Fractalkine、IFN-γ、MIP-3α、IL-12(p70)、IL-1β、IL-2、IL-6、IL-7、IL-8、TNF-α]的表达水平明显升高(P0.05或P0.01),肺癌患者非转移组与转移组血清中21种细胞因子的表达水平比较无明显差异(P0.05),肺腺癌(adenocarcinoma,AC)组血清IFN-γ与MIP-1β水平明显高于鳞癌(squamous cell carcinoma,SCC)组(均P0.05),肺SCC组血清ITAC表达水平明显高于小细胞肺癌(small cell lung cancer,SCLC)组(P0.05)。高表达的11种细胞因子在两组间表达的相关性不同。结论:肺癌患者血清中IL-6、IL-8等11种细胞因子表达升高,可能参与了肺癌发生发展,这些高表达的细胞因子或许可用于肺癌的辅助诊断,并为肺癌治疗提供新的靶标。
[Abstract]:Objective: to detect the expression of 21 cytokines (IFN-inducible T cell 伪 chemokine (IFN-inducible T cell 伪 chemotaxis), IFN- 纬 IL-10, macrophage inflammatory protein -3 伪 macrophage inflammatory protein-3 伪 MIP-3 伪) in the serum of lung cancer patients [IFN-inducible T cell 伪 chemoattractant chemoattractant TNF- 伪, macrophage inflammatory protein-3 伪 MIP-3 伪] IL-12 p70, IL-13, IL-17, IL-1 尾, IL-21, IL-4IL-23, IL-5, IL-6, IL-7, IL-8MIP-1 伪, MIP-1 尾 and TNF- 伪, and their significance. Methods: from March 2015 to March 2015, we collected and analyzed the significance of the expression of IL-12, p70, IL-13, IL-17, IL-1 尾, IL-21, IL-21, IL-23, IL-5, IL-6, IL-7, IL-8MIP-1 伪 and TNF- 伪, and their significance. In June, 40 patients with lung cancer in Shanxi Cancer Hospital; The expression of 21 cytokines in serum of 30 healthy people and 40 newly diagnosed lung cancer patients before treatment was detected by liquid phase microarray technique. Results: the expression of 11 cytokines in serum of lung cancer patients was significantly higher than that of non-metastatic lung cancer patients (P 0.05 or P0.01), and the expression of 11 cytokines in the serum of lung cancer patients was significantly higher than that of non-metastatic lung cancer patients (P 0.05 or P0.01). There was no significant difference in the expression of 21 cytokines between the two groups. The serum IFN- 纬 and MIP-1 尾 levels in the lung adenocarcinoma group were significantly higher than those in the squamous cell carcinomatous carcinoma group (all P 0.05). The serum ITAC expression level in the lung SCC group was significantly higher than that in the small cell lung group. The expression of 11 cytokines with high expression was different between the two groups. Conclusion: the expression of IL-6, IL-8 and IL-8 in serum of patients with lung cancer is increased. These high expression cytokines may be used in the auxiliary diagnosis of lung cancer and provide a new target for lung cancer treatment.
【作者单位】：蚌埠市第三人民医院肿瘤内科;山西省肿瘤医院免疫研究室;武汉市武昌医院消化科;
【基金】：国家自然科学基金资助项目(No.81272696)~~
【分类号】：R734.2

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