纳米碳示踪剂在结肠癌区域淋巴结清扫及预后的应用价值

发布时间：2018-03-03 04:00

本文选题：结肠癌　切入点：纳米碳示踪剂　出处：《青岛大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:研究纳米碳示踪技术应用于结肠癌根治术淋巴结清扫中的临床价值,并分析纳米碳示踪剂对患者预后情况的影响。方法:在2014年12月至2016年09月期间选择前来中国人民解放军第四0一医院普外科接受治疗的95例结肠癌病人作为本课题的研究对象,随机分为试验组(45例)和对照组(50例),试验组于术中在病灶周围取4~6个点浆膜下注射纳米碳注射液共1.0 m L,在手术的过程中参照黑染的淋巴结来适当调整淋巴结清扫的范围,比较两组病人之间的淋巴结清扫情况以及术后疗效。随访至2017年03月作为试验终结,比较试验组和对照组患者的生存率。结果:两组患者的一般资料之间均没有统计学上的差异(P0.05)。两组病人淋巴结清扫数分别为(14.2±4.3)枚和(11.7±3.1)枚、阳性淋巴结数分别为(5.9±2.6)枚和(3.7±1.8)枚、直径5 mm的淋巴结数分别为(5.3±2.4)枚和(2.8±1.9)枚、直径5 mm的阳性淋巴结数分别为(4.4±1.8)枚和(2.5±1.3)枚,此差异经统计学分析显示均具有统计学意义(P0.05)。试验组中被纳米炭黑染的淋巴结总数为399枚,占该组检出淋巴结总数的62.3%,其中黑染淋巴结中阳性者202枚,占试验组阳性淋巴结的75.7%,占试验组直径5 mm淋巴结的84.9%。生存分析显示试验组患者的整体预后情况比对照组要好,但两组之间差异无统计学意义(P0.05)。结论:在结肠癌根治术中采用纳米碳示踪剂能够增加结肠癌根治术中的淋巴结清扫数,并能够提高患者的预后疗效,具有很好的临床应用价值。
[Abstract]:Objective: to study the clinical value of nano-carbon tracer technique in lymph node dissection after radical resection of colon cancer. Methods: from December 2014 to September 2016, 95 patients with colon cancer were selected for general surgical treatment in the first hospital of Chinese people's Liberation Army from December 2014 to September 2016. The research object of the subject, The experimental group (n = 45) and the control group (n = 50) were randomly divided into two groups. In the experimental group, the range of lymph node dissection was adjusted according to the black-stained lymph nodes during the operation. Lymph node dissection and postoperative outcomes were compared between the two groups. Results: there was no statistical difference in the general data between the two groups. The number of lymph node dissection was 14.2 卤4.3 and 11.7 卤3.1, the number of positive lymph nodes was 5.9 卤2.6 and 3.7 卤1.8, respectively. The number of lymph nodes with diameter of 5 mm was 5.3 卤2.4 and 2.8 卤1.9 respectively, and the number of positive lymph nodes with diameter of 5 mm was 4.4 卤1.8 and 2.5 卤1.3 respectively. The total number of lymph nodes stained by nano-carbon black in the experimental group was 399, accounting for 62.3% of the total number of lymph nodes detected in the group, among which 202 were positive in the black stained lymph nodes. 75.7% of the positive lymph nodes in the trial group and 84.9% of the 5 mm diameter lymph nodes in the trial group. Survival analysis showed that the overall prognosis of the patients in the trial group was better than that in the control group. However, there was no significant difference between the two groups (P 0.05). Conclusion: the application of nano-carbon tracer in radical resection of colon cancer can increase the number of lymph node dissection in radical resection of colon cancer, and can improve the prognosis of the patients. It has good clinical application value.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R735.35

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