卵巢乳腺双原发癌42例临床分析

发布时间：2018-03-18 17:30

本文选题：卵巢癌　切入点：乳腺癌　出处：《山西医科大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的:探讨与妇科卵巢恶性肿瘤相关的卵巢乳腺双原发癌的临床特点。方法:搜集自2000年1月至2014年12月间由山西省肿瘤医院收治的42例卵巢乳腺双原发癌患者的临床病例及组织病理资料进行回顾性分析。结果:42例卵巢乳腺双原发癌患者中,第一原发癌为乳腺癌的患者共36例。该部分患者患乳腺癌后的中位生存期为247个月,1、2、5年生存率分别为83.3%(35/42)、78.6%(33/42)和66.7%(28/42);患卵巢癌后的中位生存期46个月,1、2、5年生存率分别为73.8%(31/42)、64.3%(27/42)和14.3%(6/42)。4例第一原发癌是卵巢癌的患者生存时间为42-163个月,目前仍有3位患者存活,但其中2位患者的生存时间远远小于60个月。4例有乳腺癌家族史或卵巢癌家族史的双原发癌患者,第二癌术后的5年生存率4.8%(2/42)。无恶性肿瘤家族史的33例双原发癌患者中,第二癌术后1、2、5年生存率分别为35.7%(15/42)、21.4%(9/42)、和11.9%(5/42)。结论:1.病理分期、分化程度等情况是影响卵巢乳腺双原发癌患者预后的重要因素,与首发卵巢癌患者相比,首发癌为乳腺癌的患者其生存期较长。2.有卵巢癌、乳腺癌家族史和/或既往史的人群患卵巢乳腺双原发癌的风险更高。3.对有高危因素的人群行遗传基因检测,做好筛查随访工作,做到早发现、早诊断、早治疗,避免误诊、漏诊。
[Abstract]:Objective: to investigate the clinical features of double primary ovarian carcinoma associated with gynecological ovarian malignant tumor. Methods: 42 cases of ovarian double primary carcinoma of mammary gland were collected from January 2000 to December 2014 in Shanxi Cancer Hospital. The clinical and histopathological data were retrospectively analyzed. Results among 42 patients with ovarian and breast double primary carcinoma, There were 36 patients with primary breast cancer. The median survival time after breast cancer was 247 months, and the 5-year survival rate was 83.335 / 42 / 33 / 42 and 66.7 / 2842 / 42, respectively. The median survival time of ovarian cancer was 46 months / 12, and the 5-year survival rate was 73.38 / 42 / 44.32 / 2742 respectively. And 14.3R / 42.4 patients with primary ovarian cancer had a survival time of 42 to 163 months. Three patients are still alive, but two of them have a survival time of well under 60 months. 4 patients with a family history of breast or ovarian cancer have a history of double primary cancer. The 5-year survival rate of the second cancer patients was 4.8 / 42. In 33 patients with double primary cancer without a family history of malignant tumor, the survival rates for 1 and 5 years after operation for the second cancer were 35.710 / 42or 21.40.The survival rates were 9 / 42C and 11.9b / 42.Conclusion: 1, pathological stage, The degree of differentiation is an important factor that affects the prognosis of patients with double primary ovarian cancer. Compared with the patients with primary ovarian cancer, the patients with breast cancer in the first episode have a longer survival period of .2.The patients with ovarian cancer have ovarian cancer. The population with family history and / or previous history of breast cancer had a higher risk of developing double primary ovarian cancer. 3. Genetic detection was carried out in the population with high risk factors, screening and follow-up work was done, early detection, early diagnosis, early treatment, and avoiding misdiagnosis. Missed diagnosis
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R737.31

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