跨膜丝氨酸蛋白酶4在胃癌组织中的表达及其临床意义

发布时间：2018-03-18 18:16

本文选题：丝氨酸蛋白酶　切入点：胃癌　出处：《安徽医科大学学报》2017年10期 　论文类型：期刊论文

【摘要】：目的探索跨膜丝氨酸蛋白酶4(TMPRSS 4)在胃癌组织中的表达情况及与胃癌病理学特征的关系,以及明确TMPRSS 4表达与胃癌临床预后的关系。方法使用RTq PCR技术和免疫组化检测TMPRSS 4在115例胃癌组织样本(胃癌及癌旁组织)中的表达情况;分析TMPRSS 4表达水平与胃癌病理学特征和预后的关系。结果 RT-q PCR结果提示胃癌组织中的TMPRSS 4 mRNA水平显著高于其在匹配癌旁组织中的表达水平,差异有统计学意义(P0.05)。免疫组化结果显示TMPRSS 4在胃癌组织中的表达比在良性组织高(56.5%vs 19.5%,P0.001)。TMPRSS 4的过度表达与胃肿瘤的分化程度、淋巴道转移及TNM分期肿瘤显著相关(P0.01)。TMPRSS 4是影响胃癌总体生存率及无病生存率的独立因素。结论 TMPRSS 4高表达与胃癌患者相关临床病理特征及患者的预后密切相关,TMPRSS 4有可能作为一个常规的胃癌的生物标志物,在一定程度上预测肿瘤的侵袭转移。
[Abstract]:Objective to investigate the expression of transmembrane serine protease 4 (TMPRSS4) in gastric carcinoma and its relationship with the pathological features of gastric cancer. Methods RTq PCR technique and immunohistochemistry were used to detect the expression of TMPRSS 4 in gastric cancer tissues (gastric cancer and adjacent tissues). Results the results of RT-q PCR showed that the expression of TMPRSS 4 mRNA in gastric cancer tissues was significantly higher than that in matched adjacent tissues. The immunohistochemical results showed that the expression of TMPRSS 4 in gastric carcinoma was higher than that in benign tissues, and the overexpression of TMPRSS 4 in gastric carcinoma was higher than that in benign tissues. Lymphatic metastasis and TNM stage were significantly associated with tumor P0.01. TMPRSS4 was an independent factor affecting the overall survival rate and disease-free survival rate of gastric cancer. Conclusion the high expression of TMPRSS 4 is closely related to clinicopathological features and prognosis of patients with gastric cancer. TMPRSS4 may be a normal biomarker for gastric cancer. To some extent, the invasion and metastasis of tumor are predicted.
【作者单位】：安徽医科大学附属省立医院普外科;
【基金】：安徽省卫生厅医学科研课题(编号:13zc011)
【分类号】：R735.2

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