乳腺癌患者血栓弹力图与常规凝血试验相关性分析

发布时间：2018-03-19 17:04

本文选题：血栓弹力图　切入点：凝血功能　出处：《中国输血杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的探讨乳腺癌患者血栓弹力图(TEG)各参数与常规凝血试验指标的相关性,评价2种方法在检测乳腺癌患者凝血功能中的作用。方法选取2014年在本院接受治疗的270例女性乳腺癌患者作为观察组,乳腺良性疾病患者210例作为对照组,2组均进行TEG与常规凝血试验,将TEG检测的各参数结果与凝血四项和血小板计数结果进行相关性分析,并评价TEG与常规凝血试验指标对诊断乳腺癌患者高凝状态的灵敏度和特异度。结果与乳腺良性疾病患者相比,乳腺癌患者PT(10.61±0.83)s vs(11.02±0.91)s和APTT(30.37±4.60)s vs(32.70±5.07)s,明显缩短;FIB(2.75±0.55)g/L vs(2.50±0.47)g/L及Plt(250.33±65.34)×109L-1vs(233.74±51.83)×109L-1明显升高,P均0.05;乳腺癌组R值(3.69±0.92)min vs(4.30±1.00)min和K值(1.47±0.50)min vs(1.70±0.39)min明显缩短,Angle角(69.54±5.38)deg vs(66.55±4.37)deg、MA值(64.29±4.37)mm vs(62.24±3.58)mm和CI值(2.39±1.35)vs(1.42±1.18)明显增大,P均0.05,表明患者存在血液高凝状态。R值与活化部分凝血活酶时间(APTT)呈正相关性,与Plt呈负相关性(P0.05);K值与APTT、TT呈正相关性,与FIB、Plt呈负相关性(P0.05);Angle角与APTT、TT呈负相关性,与FIB、Plt呈正相关性(P0.05);MA与PT、APTT、TT呈负相关性,与FIB、Plt呈正相关性(P0.05);CI与APTT、TT呈负相关,与FIB、Plt呈正相关性(P0.05)。TEG和常规凝血试验指标对乳腺癌高凝患者的诊断灵敏度和特异性的一致性差。结论 TEG不仅能较全面地反映乳腺癌患者体内的凝血状况,而且与常规凝血试验具有相关性,二者结合能够更全面准确地反映患者的凝血状况。
[Abstract]:Objective to investigate the correlation between the parameters of thromboelastogram (TEG) and the indexes of routine coagulation test in patients with breast cancer. To evaluate the role of two methods in detecting the coagulation function of breast cancer patients, 270 female breast cancer patients who were treated in our hospital in 2014 were selected as the observation group. Two hundred and ten patients with benign breast disease were treated with TEG and routine coagulation test. The correlation between the parameters of TEG and the four items of coagulation and platelet count was analyzed. The sensitivity and specificity of TEG and conventional coagulation test in the diagnosis of hypercoagulable state of breast cancer were evaluated. In breast cancer patients, PT(10.61 卤0.83s vs(11.02 卤0.91s and APTT(30.37 卤4.60s vs(32.70 卤5.07s significantly shortened the values of vs(2.50 卤0.47g / L and Plt(250.33 卤65.34 脳 10 9L -1 vs 233.74 卤51.83) 脳 10 9L -1 (P < 0.05); in breast cancer patients, the R value was 3.69 卤0.92min, vs(4.30 卤1.00min, and K value 1.47 卤0.50min vs(1.70 卤0.39g / min, respectively. All of them were significantly shorter than those in breast cancer patients (69.54 卤5.38deg vs(66.55 卤4.37odegdegdegma 64.29 卤4.37mm vs(62.24 卤3.58mm and CI 2.39 卤3.35vs1.1842 卤1.1842). The value of state. R was positively correlated with activated partial thromboplastin time (APTT). There was a negative correlation between P0.05K and Plt, a negative correlation between P0.05T and APTTTT, a negative correlation between P0.05V angle and APTTTT, a positive correlation between P0.05T and Plt, a negative correlation between P0.05T and APTTTT, a negative correlation between P0.05CI and APTTTT with FIBPlt, a negative correlation between P0.05T and APTTTT, and a negative correlation between P0.05CI and APTTTT with FIBPlt. The diagnostic sensitivity and specificity of TEG in patients with breast cancer with hypercoagulability were poor. Conclusion TEG can not only reflect the coagulation status of breast cancer patients, but also can reflect the blood coagulation status of breast cancer patients. In addition, there is a correlation with the routine coagulation test, and the combination of the two can more comprehensively and accurately reflect the coagulation status of the patients.
【作者单位】：郑州大学附属肿瘤医院输血科;
【分类号】：R737.9

【相似文献】