ALDH1A1在舌癌及淋巴结中的表达及其临床意义

发布时间：2018-03-23 18:47

本文选题：舌鳞状细胞癌　切入点：淋巴结　出处：《口腔医学研究》2017年03期

【摘要】：目的:检测乙醛脱氢酶1A1(aldehyde dehydrogenase1A1,ALDH1A1)在舌鳞状细胞癌(tongue squamous cell carcinoma,TSCC)原发灶及颈淋巴结标本中的表达水平,分析其与患者临床病理特征及预后的关系。方法:采用免疫组化SP法检测50例舌鳞状细胞癌原发灶和10例正常舌组织、29例转移淋巴结和9例未转移淋巴结标本中ALDH1A1的表达水平。结果:舌鳞状细胞癌原发灶中ALDH1A1表达高于正常舌组织,差异有统计学意义(P0.05);转移淋巴结中ALDH1A1表达高于未转移淋巴结,差异有统计学意义(P0.05)。在舌鳞状细胞癌原发灶中,ALDH1A1表达与患者的临床分期、有无淋巴结转移、原发灶大小及组织学分级有关(P0.05);在淋巴结中,ALDH1A1表达与患者的临床分期、有无淋巴结转移及原发灶大小有关(P0.05)。Kaplan-Meier分析表明舌鳞状细胞癌原发灶ALDH1A1高表达提示不良预后。结论:ALDH1A1的表达与舌鳞状细胞癌的生物学行为及预后密切相关,有望作为舌鳞状细胞癌预后相关因子,可能为舌鳞状细胞癌提供新的治疗靶点。
[Abstract]:Objective: to detect the expression of 1A1(aldehyde dehydrogenase 1A1(aldehyde dehydrogenase 1A 1 (ALDH1 A1) in primary squamous cell carcinoma of tongue squamous cell carcinoma (TSCC) and its cervical lymph nodes. Methods: immunohistochemical SP method was used to detect the metastatic lymph nodes in 50 cases of squamous cell carcinoma of tongue, 29 cases of metastatic lymph nodes in normal tongue tissue and 9 cases of non-metastatic lymph nodes. Results: the expression of ALDH1A1 in primary tumor of tongue squamous cell carcinoma was higher than that in normal tongue tissue. The expression of ALDH1A1 in metastatic lymph nodes was significantly higher than that in non-metastatic lymph nodes (P 0.05). The size and histological grade of primary lesions were related to P0.05.The expression of ALDH1A1 in lymph nodes was correlated with the clinical stage of the patients. The high expression of ALDH1A1 in primary tumor of tongue squamous cell carcinoma is associated with lymph node metastasis and the size of primary tumor. Conclusion the high expression of ALDH1A1 in primary tumor of tongue squamous cell carcinoma is closely related to the biological behavior and prognosis of tongue squamous cell carcinoma. It is expected to be a prognostic factor in tongue squamous cell carcinoma and may provide a new therapeutic target for tongue squamous cell carcinoma.
【作者单位】：天津医科大学;天津市口腔医院;
【分类号】：R739.86

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