肿瘤多药耐药性产生机制及其逆转的研究现状

  本文关键词：肿瘤多药耐药性产生机制及其逆转的研究现状，由笔耕文化传播整理发布。

肿瘤多药耐药性产生机制及其逆转的研究现状

摘要：肿瘤严重威胁着人民群众的生命健康,它的防治一直是医学界研究的热点。在肿瘤治疗中,手术治疗、放疗、化疗是最传统的3种治疗方案,其中化疗占据着不可替代的重要地位。有些肿瘤在经历了最初有效化疗后,仍难免复发,这其中一个很重要的原因就是肿瘤细胞对化疗药物产生了多药耐药性。合理的联合化疗虽能最大限度发挥细胞毒作用,但都可因多药耐药(Multidrug Resistance,MDR)的出现而宣告失败。因此,逆转肿瘤多药耐药,提高肿瘤细胞对化疗药物的敏感性已成为肿瘤研究领域的一大热点。本文就这肿瘤多药耐药机制及其逆转的研究现状做一综述。
Tumor seriously threat to people's lives and health.It has been the hot medical research.In the treatment of cancer,surgery,radiotherapy,Chemotherapy is the most traditional of the three types of treatment programs.Chemotherapy occupy an important position.Some tumor experienced in the first effective cancer chemotherapy,but the relapse is inevitable.A reason for this is that a number of tumor cells get chemotherapeutic drug resistance.Reasonable chemotherapy are able to play a role in cytotoxic effect,but a major obstacle limiting the successful chemotherapy of tumor is the emergence of the Multi-drug Resistance.Therefore,the reversal of tumor resistance and increasing the sensitivity of tumor cells to chemotherapeutic drugs has become a hot area of tumor research.This paper presents a review on the current state of research.

  本文关键词：肿瘤多药耐药性产生机制及其逆转的研究现状，由笔耕文化传播整理发布。