福建省仙游县胃癌环境危险因素及其交互作用:基于病例对照研究

发布时间：2018-03-28 16:58

本文选题：胃癌　切入点：交互作用　出处：《环境与职业医学》2017年01期

【摘要】：[目的]通过病例对照研究,探讨仙游县胃癌发病的危险因素及其存在的交互作用。[方法]选取2013年5月—2015年6月期间经病理确诊并在仙游县生活达10年或以上的胃癌病例433例,选取866位健康人作为对照进行1∶2个体匹配,进行面对面问卷调查。构建分类回归树发现存在交互作用的因素并应用条件logistic回归分析各因素可能存在的相乘交互作用。[结果]多因素条件logistic回归分析结果显示:饮食速度快(OR=1.321,95%CI:1.055~1.653)、食物较硬(OR=1.709,95%CI:1.344~2.174)、食用腌菜(OR=1.359,95%CI:1.083~1.704)、吸烟(OR=1.875,95%CI:1.261~2.786)、慢性萎缩性胃炎(OR=2.395,95%CI:1.228~4.672)、肿瘤家族史(OR=1.545,95%CI:1.061~2.250)、接触农药(OR=2.840,95%CI:2.003~4.025)及对家庭现状不满意(OR=2.383,95%CI:1.708~3.326)为仙游县胃癌发病的主要危险因素;而食用新鲜蔬菜(OR=0.653,95%CI:0.485~0.878)、食用菌(OR=0.657,95%CI:0.494~0.872)、海带(OR=0.671,95%CI:0.500~0.901)及洋葱大葱(OR=0.638,95%CI:0.518~0.787)为其保护因素。交互作用结果显示:接触农药和食用腌菜、食物硬,食用腌菜和饮食速度快、吸烟之间存在相乘交互作用。[结论]接触农药、食用腌菜、食物硬、饮食速度快及吸烟在仙游县胃癌发生、发展中存在交互作用。
[Abstract]:[objective] to adopt a case-control study, To explore the risk factors of gastric cancer and its interaction in Xianyou County. [methods] 433 cases of gastric cancer diagnosed pathologically from May 2013 to June 2015 and living in Xianyou County for 10 years or more were selected. 866 healthy persons were selected as control group for 1:2 individual matching. Face-to-face questionnaire survey was carried out. The factors of interaction were found by constructing the classification regression tree and the multiplicative interaction of various factors was analyzed by conditional logistic regression analysis. [results] the results of multivariate conditional logistic regression analysis showed that there were interaction factors. The main risk factors for gastric cancer were as follows: fast diet: 1.321 ~ 95CII: 1.05555: 1.653, hard food: OR1.709 / 95CI1.3442.174, eating pickled vegetables OR1.35995 9595: CI1.0831.704, smoking OR1.87595CI1.2611.786, chronic atrophic gastritis 2.39595CI1.2284.672CI1.2284.672, cancer family history 1.54595CI1.0612.250, exposure to the pesticide OR2.840400.2.34.00) and the family dissatisfied with the status quo of the disease. And the protective factors are the consumption of fresh vegetables: CIW 0.48595: 0.485N 0.878, the edible fungus ORO 0.65795 CI: 0.494 0.872m, the kelp 0.671n 9595 + 0.901) and the onion and scallions OR0.63895CI0.518180.787). The interactive results show that the food is exposed to pesticides and pickles, the food is hard, the food is hard, and the speed of eating pickled vegetables and eating vegetables is fast, and the food is hard, and the food is hard, the food is hard, the food is hard, the food is hard, the food is hard, the food is hard, the food is hard, the food is hard, the food is hard, the food is hard, and the food consumption rate is fast. [conclusion] exposure to pesticides, eating pickled vegetables, hard food, fast diet and smoking have interaction in the development of gastric cancer in Xianyou County.
【作者单位】：福建医科大学公共卫生学院;福建省仙游县医院;福建卫生职业技术学院;
【基金】：莆田市仙游县政府基金(编号:2013B008) 福建省自然科学基金(编号:2015J01673)
【分类号】：R735.2

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