还原型谷胱甘肽在原发性肝癌介入治疗后保肝作用中的临床应用

发布时间：2018-04-03 05:20

本文选题：还原型谷胱甘肽　切入点：肝癌　出处：《介入放射学杂志》2017年02期

【摘要】：目的探讨还原型谷胱甘肽在原发性肝癌介入治疗后的保肝作用。方法回顾性分析2010年1月—2013年6月收治的原发性肝癌患者110例,按照随机数字表法分为对照组50例和治疗组60例,均给予肝动脉化学性栓塞和灌注治疗。对照组,静脉滴注维生素C 2.0 g,维生素B6 0.2 g,肌苷2.0 g,以及支链氨基酸250 ml,每日1次,术后连续使用1周;治疗组,在前述基础用药上加用还原型谷胱甘肽1.8 g,以5%葡萄糖溶液250 ml配伍静脉滴注。同时检测术前和术后1周各项肝功能指标,进行两组间比较。结果治疗前两组肝功能、病情无明显差异。介入治疗1周后,治疗组和对照组转氨酶(ALT、AST)、总胆红素(TBIL)均明显升高(P0.05),血清前白蛋白(PA)均明显降低(P0.05);治疗组各项指标变化明显优于对照组(P0.05)。结论还原型谷胱甘肽能明显改善原发性肝癌介入治疗引起的肝功能损害,有很好的临床应用价值。
[Abstract]:Objective to investigate the protective effect of reduced glutathione on primary liver cancer after interventional therapy.Methods from January 2010 to June 2013, 110 patients with primary liver cancer were divided into control group (n = 50) and treatment group (n = 60). All patients were treated with hepatic artery chemoembolization and perfusion.In the control group, vitamin C 2.0 g, vitamin B 6 0.2 g, inosine 2.0 g, and branched-chain amino acid 250ml once a day were injected intravenously for one week after operation.Glutathione 1.8 g was added to the above basic drug, and 250 ml glucose solution was used for intravenous drip.At the same time, the indexes of liver function were measured before and 1 week after operation, and compared between the two groups.Results there was no significant difference in liver function between the two groups before treatment.After one week of interventional therapy, the levels of transaminase, total bilirubin and total bilirubin were significantly increased in both the treatment group and the control group, and the levels of serum prealbumin (PAA) were significantly lower than that in the control group (P 0.05), and the changes of each index in the treatment group were significantly better than those in the control group (P 0.05).Conclusion reduced glutathione can obviously improve liver function damage caused by interventional therapy for primary liver cancer, and has good clinical application value.
【作者单位】：徐州医科大学附属医院介入放射科;
【分类号】：R735.7

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