Ⅰ期肺腺癌新分类组织亚型与EGFR突变的关系

发布时间：2018-04-03 18:11

  本文选题：肺肿瘤　切入点：腺癌　出处：《肿瘤》2017年01期

【摘要】：目的 :按照2011年国际肺癌研究学会(International Association for the Study of Lung Cancer,IASLC)/美国胸科学会(American Thoracic Society,ATS)和欧洲呼吸学会(European Respiratory Society,ERS)制定的国际多学科肺腺癌分类标准,探讨Ⅰ期肺腺癌的组织亚型与表皮生长因子受体(epidermal growth factor receptor,EGFR)突变间的关系。方法 :应用二代测序技术检测100例明确组织亚型的Ⅰ期肺腺癌组织标本EGFR的突变情况,分析肺腺癌不同组织亚型和肺腺癌患者的临床病理特征与EGFR突变间的关系。结果 :100例肺腺癌患者中,49例(49.0%)发生EGFR突变。其中,贴壁为主亚型EGFR突变23例(63.9%),乳头为主亚型突变5例(62.5%),腺泡为主亚型突变21例(46.7%),微乳头为主亚型和固态或黏液为主亚型均无突变。Ⅰ期肺腺癌EGFR突变与组织亚型相关(P=0.002)。存在贴壁组织成分的腺癌中EGFR突变率(60.8%)明显高于缺乏贴壁组织成分的腺癌(36.7%,P=0.018),存在固态/黏液组织成分的腺癌中EGFR突变率(20.0%)明显低于缺乏固态/黏液组织成分的腺癌(54.1%,P=0.015)。EGFR突变与肺腺癌的分化程度有关(P=0.001),而与性别、年龄、吸烟、肿瘤大小和胸膜转移均无关(P值均0.05)。结论 :Ⅰ期肺腺癌中贴壁为主亚型或存在贴壁组织成分的腺癌具有较高的EGFR突变率,EGFR突变与肺腺癌的分化程度有关。
[Abstract]:Objective: according to the International Association for the Study of Lung Cancer IASLCN / American Thoracic Society ATS (2011) and the European Respiratory Society (ERS) of the European Society of Respiratory Sciences, the international classification criteria for lung adenocarcinoma were established in accordance with the International Association for the Study of Lung Cancer IASC / American Thoracic Society ATS (2011) and the European Respiratory Society (ERS) of the European Society of Respiratory Sciences (ESR).To investigate the relationship between histological subtypes of stage I lung adenocarcinoma and epidermal growth factor receptor (EGFR) mutation in epidermal growth factor receptor (EGFR).Methods: second generation sequencing technique was used to detect the mutation of EGFR in 100 cases of stage I lung adenocarcinoma with definite tissue subtypes. The relationship between EGFR mutation and clinicopathological features of different subtypes of lung adenocarcinoma and lung adenocarcinoma was analyzed.Results EGFR mutation occurred in 49 out of 100 lung adenocarcinoma patients.鍏朵腑,璐村�佷负涓讳簹鍨婨GFR绐佸彉23渚，

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