PNI及HGB评估中晚期非小细胞肺癌患者预后的临床价值

发布时间：2018-04-18 19:26

  本文选题：预后营养指数 + 血红蛋白　； 参考：《山东大学学报(医学版)》2017年04期

【摘要】：目的探讨预后营养指数(PNI)及血红蛋白(HGB)评估中晚期非小细胞肺癌患者预后的临床价值。方法选取2013年8月至2015年8月首次确诊的、符合本研究条件的中晚期非小细胞肺癌患者的临床资料;通过电子病历系统、门诊及电话等方法对所有患者进行随访,随访截止到患者死亡或2016年8月;根据PNI中位数(46.52)及HGB中位数(115 g/L)将患者分为高PNI组、低PNI组及高HGB组、低HGB组;通过单因素及多因素分析PNI及HGB对患者总生存期(OS)的影响;制作两组患者的Kaplan-Meier生存曲线,同时行Log-rank检验。通过单因素分析PNI及HGB相关影响因素。结果单因素变量分析示首次确诊时年龄≥65岁、吸烟指数≥400、PNI46.52、HGB115 g/L的患者OS明显低于年龄65岁、吸烟指数400、PNI≥46.52、HGB≥115 g/L的患者OS(P0.05);PNI与患者年龄、临床分期、胸腔积液及吸烟指数密切相关(P0.05);HGB与患者年龄、体质量下降率密切相关(P0.05)。多因素分析示仅PNI及HGB对患者OS的影响有统计学意义[Exp(B)=2.180,P0.001;Exp(B)=2.032,P=0.001]。绘制Kaplan-Meier生存曲线同时行Log-rank检验示,高PNI组与低PNI组患者、高HGB组与低HGB组患者OS差异有统计学意义(P0.001)。结论PNI及HGB可作为中晚期非小细胞肺癌患者预后的独立危险因素。
[Abstract]:Objective to evaluate the prognostic value of prognostic nutrition index (PNI) and hemoglobin (HGB) in patients with advanced non small cell lung cancer (NSCLC).Methods the clinical data of patients with advanced non-small cell lung cancer (NSCLC), who were first diagnosed from August 2013 to August 2015, were followed up by electronic medical record system, outpatient service and telephone, etc.According to the median of PNI (46.52) and HGB (115g / L), the patients were divided into three groups: high PNI group, low PNI group and high HGB group, low HGB group, univariate and multivariate analysis of the influence of PNI and HGB on total survival time.The Kaplan-Meier survival curves of the two groups were made and the Log-rank test was performed at the same time.The related factors of PNI and HGB were analyzed by univariate analysis.Results the univariate analysis showed that the patients with smoking index 鈮，

本文编号：1769726