ELAM-1靶向肿瘤转移的研究进展

发布时间：2018-05-02 13:42

本文选题：E选择素 + 肿瘤转移　；参考：《中华肿瘤防治杂志》2017年02期

【摘要】：目的肿瘤的转移是恶性肿瘤致死的主要原因之一,也是影响肿瘤治疗与预后的重要因素,E选择素(endothelial leukocyte adhesion molecule-1,ELAM-1)是导致肿瘤转移的关键步骤之一,以ELAM-1为靶点成为肿瘤靶向治疗的新研究热点。本研究总结国内外对ELAM-1靶向肿瘤转移的研究进展。方法应用ScienceDirect、PubMed及CNKI期刊全文数据库检索系统,分别以"肿瘤转移和靶向治疗、ELAM-1和肿瘤转移"等为关键词,检索2006-01-2016-12的国内外相关文献,共检索到英文文献6 092篇,中文文献7 063篇。纳入标准:(1)ELAM-1的生物学特点与生物学功能。(2)ELAM-1与常见肿瘤转移的关系。(3)ELAM-1靶向性调控与肿瘤转移情况。依据纳入排除标准,符合分析的文献27篇。结果 ELAM-1是细胞黏附分子家族的一员,其配体为唾液酸化的路易斯寡糖[sialyl-Lewis x,sLe(x)]或[sialylLewis a,sLe(a)]。通过ELAM-1单克隆抗体、ELAM-1分子偶联药物、ELAM-1配体sLe(x)表达抑制剂、ELAM-1/配体相互作用拮抗药物及ELAM-1表达抑制剂等可以抑制肿瘤转移、改善肿瘤预后。结论 ELAM-1与其配体的相互作用是介导肿瘤转移的关键,将ELAM-1及其调控路径作为治疗的靶点将有望成为肿瘤靶向治疗的突破口。
[Abstract]:Objective Metastasis is one of the main causes of death from malignant tumors and an important factor affecting the treatment and prognosis of cancer. E-selectin leukocyte adhesion molecule-1 (ELAM-1) is one of the key steps leading to tumor metastasis. ELAM-1 as a target has become a new research hotspot in tumor targeting therapy. This study summarizes the research progress of ELAM-1 targeted tumor metastasis at home and abroad. Methods using the Science Direct PubMed and CNKI journal full-text database retrieval system, we searched 6 092 articles in English and 7 063 articles in Chinese with the keywords of "tumor metastasis and targeted treatment of ELAM-1 and tumor metastasis". Biological characteristics and Biological function of ELAM-1. The relationship between ELAM-1 and tumor Metastasis. The targeting Regulation of ELAM-1 and tumor Metastasis. According to the exclusion criteria, 27 articles were analyzed. Results ELAM-1 is a member of the cell adhesion molecule family, and its ligand is sialy-acidified Lewis oligosaccharide (sialyl-Lewis xanthosyl Leux) or [sialylLewis Agnes Lehina]. The inhibition of ELAM-1 / ligand interaction antagonists and ELAM-1 expression inhibitors can inhibit tumor metastasis and improve tumor prognosis through ELAM-1 monoclonal antibody ELAM-1 molecular coupled drug (ELAM-1) ligand sLeM-1 / ligand interaction antagonist. Conclusion the interaction between ELAM-1 and its ligand is the key to mediate tumor metastasis, and it is expected that ELAM-1 and its regulatory pathway will be a breakthrough in tumor targeting therapy.
【作者单位】：广西医科大学附属肿瘤医院医学影像诊断中心;
【基金】：国家自然科学基金(81260334;814604521)
【分类号】：R73-37

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