芍药汤加减联合XELOX方案治疗湿热蕴结型结直肠癌术后的临床疗效观察

发布时间：2018-05-10 19:50

本文选题：芍药汤加减 + 结直肠癌术后　；参考：《黑龙江中医药大学》2017年硕士论文

【摘要】：目的:探究芍药汤加减联合XELOX方案治疗湿热蕴结型结直肠癌术后的临床疗效。方法:纳入湿热蕴结型结直肠癌术后患者80例,采用随机数字表法分成治疗组40例、对照组40例,对照组予XELOX方案,治疗组予XELOX方案联合芍药汤加减,共观察4周期。运用统计学方法评价治疗前后中医证候积分、卡氏评分、肿瘤标志物、化疗后毒副反应等变化,以及安全性指标。结果:1.在改善中医证候积分方面,治疗4周期后比较,治疗组积分下降程度较对照组明显,差异有统计学意义(P0.05)。2.比较两组单项中医证候疗效,在腹胀腹痛、便溏不爽、肛门灼热、里急后重、倦怠乏力、食欲不振、大便下血等,治疗组缓解均优于对照组,差异有统计学意义(P0.05)。3.在Karnofsky评分疗效方面,治疗4周期后比较,治疗组疗效优于对照组,差异有统计学意义(P0.05)。4.在降低肿瘤标志物CEA、CA199水平方面,治疗4周期后,分别对比两组CEA、CA199水平降低程度,治疗组较对照组更为明显,差异有显著的统计学意义(P0.01)。5.在不良反应方面,治疗组化疗不良反应如恶心呕吐、腹泻、手足综合征及神经毒性的发生率较对照组明显减低,差异有统计学意义(P0.05)。结论:1.芍药汤加减联合化疗可以降低湿热蕴结型结直肠癌术后患者的中医证候积分,减轻其临床症状,提高患者Karnofsky评分,改善患者生活质量。2.芍药汤加减联合化疗可以降低肿瘤标记物CEA、CA199水平。3.芍药汤加减可以减轻化疗引起的不良反应。
[Abstract]:Objective: To explore the clinical effect of Peony Decoction plus subtraction combined with XELOX regimen in the treatment of damp heat implication colorectal cancer. Methods: 80 patients were included in the treatment group, 40 cases were divided into the treatment group, 40 cases in the control group, the control group were given the XELOX scheme, the treatment group was given the XELOX scheme combined with the peony soup, and 4 cases were treated with the treatment group. Cycle. Statistical methods were used to evaluate the scores of TCM syndromes, Chi's score, tumor markers, chemotherapy and side effects, as well as safety indicators. Results: 1. in the improvement of TCM syndrome scores, after 4 cycles of treatment, the degree of integration decreased significantly compared with the control group, the difference was statistically significant (P0.05).2. comparison. The curative effect of two groups of TCM syndromes, in abdominal distention and abdominal pain, loose stool, burning anus, tiredness, lassitude, loss of appetite, stool blood and so on, the treatment group was better than the control group, the difference was statistically significant (P0.05).3. in the Karnofsky score effect, after treatment 4 cycles, the treatment group was better than the control group, the difference was statistically significant. The difference was statistically significant Meaning (P0.05).4. in reducing tumor markers CEA, CA199 level, after 4 cycles, compared two groups of CEA, CA199 level decreased, the treatment group is more obvious than the control group, the difference has significant statistical significance (P0.01).5. in adverse reactions, treatment group adverse reactions such as nausea, vomiting, diarrhea, hand foot syndrome and nerve The incidence of toxicity was significantly lower than that of the control group (P0.05). Conclusion: 1. the combined chemotherapy of peony decoction can reduce the TCM syndrome score of the patients with wet heat accumulation of colorectal cancer, reduce its clinical symptoms, improve the patient's Karnofsky score, and improve the quality of life of the patients.2. peony soup combined chemotherapy can be reduced. Low tumor markers CEA, CA199 level.3. and peony decoction can alleviate the adverse reactions caused by chemotherapy.

【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R735.34

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