急性白血病患儿血清铁调素和炎性因子白介素6的表达及临床意义

发布时间：2018-05-10 19:59

  本文选题：铁调素 + 急性白血病　； 参考：《中华医院感染学杂志》2017年06期

【摘要】：目的探究铁调素和白介素6的表达与急性白血病(AL)患儿贫血的相关性。方法选取2013年9月-2015年1月医院小儿血液内科收治的AL患儿30例为研究对象,按治疗前及缓解后分为初治组与缓解组;同期选取于医院体检的健康儿童30例纳入对照组;实验应用酶联免疫吸附试验(ELISA)法检测研究对象血清铁调素及IL-6水平,应用血液分析仪检测研究对象血红蛋白(Hb)水平;并分析AL患儿铁调素与IL-6、Hb的相关关系。结果急性白血病患儿初治组、缓解组与对照组血清铁调素分别为(82.87±37.21)ng/mL、(50.55±33.46)ng/mL、(17.20±7.91)ng/mL;IL-6水平分别为(15.75±5.04)pg/mL、(10.89±3.96)pg/mL、(7.77±4.71)pg/mL;血红蛋白的水平分别为(79.97±20.58)g/L、(109.6±20.66)g/L、(129.33±9.22)g/L;铁调素、IL-6、血红蛋白在各组间表达差异均有统计学意义(P0.05);初治组铁调素与IL-6呈正相关关系(r=0.709;P=0.000),铁调素水平与Hb浓度呈负相关关系(r=-0.414;P=0.023)。结论 AL患儿铁调素的表达与临床贫血严重程度呈正相关,而且贫血原因可能由于炎性因子所诱发的铁调素的表达上调有关。
[Abstract]:Objective to investigate the relationship between the expression of iron modulin and interleukin 6 and anemia in children with acute leukemia. Methods from September 2013 to January 2015, 30 children with AL were divided into primary treatment group and remission group according to their pre-treatment and post-remission period, and 30 healthy children who were examined in hospital at the same time were included in the control group. The serum levels of iron modulin and IL-6 were detected by Elisa, and the hemoglobin HB level was detected by blood analyzer, and the correlation between iron modulin and IL-6 Hb in children with AL was analyzed. Results the initial treatment group of acute leukemia children, 缂撹В缁勪笌瀵圭収缁勮��娓呴搧璋冪礌鍒嗗埆涓，

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