肠型胃癌和弥漫型胃癌的临床特点及预后研究

发布时间：2018-05-20 05:06

本文选题：胃肿瘤 + Lauren分型　；参考：《中国全科医学》2017年13期

【摘要】：目的探讨肠型胃癌和弥漫型胃癌的临床特点及预后。方法选取2007-01-01至2015-12-30在长治医学院附属和平医院外科病房手术治疗的胃癌患者392例,其中肠型231例(58.9%),弥漫型161例(41.1%)。建立胃癌流行病学调查问卷,并由经过培训的专业人员按统一标准采集胃癌患者信息,包括基本情况(性别、年龄、身高、体质量、文化程度、婚姻状况、血型、幽门螺杆菌感染、肿瘤家族史)、生活方式及习惯(吸烟、饮酒、进食速度、进食烫食、进食酸菜/咸菜/泡菜、进食油炸食品)及病理诊断与临床分期等;并由本院中心实验室具有硕士及以上学历人员对患者进行电话随访,询问生存情况,随访截至2015-12-30。结果肠型与弥漫型胃癌患者性别、体质指数(BMI)、文化程度、婚姻状况、血型、幽门螺杆菌感染、肿瘤家族史比较,差异无统计学意义(P0.05);肠型与弥漫型胃癌患者年龄比较,差异有统计学意义(P0.05)。肠型与弥漫型胃癌患者吸烟、饮酒比较,差异有统计学意义(P0.05);肠型与弥漫型胃癌患者进食速度、进食烫食、进食酸菜/咸菜/泡菜、进食油炸食品比较,差异无统计学意义(P0.05)。肠型与弥漫型胃癌患者T期、M期比较,差异无统计学意义(P0.05);肠型与弥漫型胃癌患者N期比较,差异有统计学意义(P0.05)。340例胃癌患者完成随访,随访率为86.7%;截至随访日期,肠型胃癌患者生存率为66.5%(129/194),中位生存时间为24个月;弥漫型胃癌患者生存率为52.7%(77/146),中位生存时间为18个月。肠型与弥漫型胃癌患者生存曲线比较,差异有统计学意义(P0.05)。结论不同Lauren分型胃癌临床特点和预后不同。Lauren分型在胃癌治疗及预防中起一定的决策作用。
[Abstract]:Objective to investigate the clinical features and prognosis of intestinal and diffuse gastric cancer. Methods 392 patients with gastric cancer were selected from January 1, 2007 to May 12, 2015-30 in the surgical ward of the affiliated Peace Hospital of Changzhi Medical College. 231 cases of intestinal type and 161 cases of diffuse type were selected. A questionnaire on gastric cancer epidemiology was established and trained professionals were trained to collect information on gastric cancer patients according to uniform criteria, including basic information (sex, age, height, body mass, education, marital status, blood type). Helicobacter pylori infection, family history of cancer, lifestyle and habits (smoking, drinking, eating speed, eating hot food, eating pickles / pickles, eating fried food), pathological diagnosis and clinical stages. And from the central laboratory of our hospital with master's degree and above to carry on the telephone follow-up to the patient, inquire the survival condition, follow up to 2015-12-30. Results there was no significant difference in sex, BMI, education, marital status, blood group, Helicobacter pylori infection, family history of tumor between intestinal type and diffuse type of gastric cancer (P 0.05). The difference was statistically significant (P 0.05). There was significant difference in smoking and drinking between intestinal type and diffuse type of gastric cancer (P 0.05), but there was no significant difference between intestinal type and diffuse type of gastric cancer in terms of eating speed, hot food, pickle / pickle and fried food (P 0.05). There was no significant difference in T phase M stage between intestinal type and diffuse type of gastric cancer, but there was no significant difference between intestinal type and diffuse type of gastric cancer in N stage, and there was significant difference in P 0.05% and 340 cases of gastric cancer with a follow-up rate of 86.7%. The survival rate of patients with intestinal type gastric cancer was 12.9 / 194, the median survival time was 24 months, and the survival rate of diffuse gastric cancer patients was 52.777 / 146, with a median survival time of 18 months. There was significant difference in survival curve between intestinal type and diffuse type of gastric cancer (P 0.05). Conclusion the clinical characteristics and prognosis of gastric cancer with different Lauren types are different. Lauren's classification plays a decisive role in the treatment and prevention of gastric cancer.
【作者单位】：长治医学院预防医学系流行病与卫生统计学教研室;长治医学院附属和平医院中心实验室;
【基金】：山西省基础研究计划项目(2015021185) 国家自然科学基金资助项目(81302518) 山西省长治医学院创新团队(CX201403)
【分类号】：R735.2

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