广西地区家族性乳腺癌临床病理特征及预后的相关研究

发布时间：2018-05-25 04:13

本文选题：乳腺肿瘤 + 病理学　；参考：《中华疾病控制杂志》2017年05期

【摘要】：目的比较家族性乳腺癌和散发性乳腺癌患者的临床病理特征,揭示家族性乳腺癌独特的临床病理学及分子生物学特性。方法回顾性分析广西医科大学第一附属医院胃肠腺体外科2013年1月~2014年1月期间收治中的445例女性乳腺癌患者临床病理资料,其中家族性乳腺癌患者43例,散发性乳腺癌402例。比较分析两组临床病理特征、分子生物学行为以及复发、转移等情况。结果在组织学分级中家族性乳腺癌患者分为III级所占的比例(37.2%)高于散发性乳腺癌患者所占的比例(22.6%),差异有统计学意义(X~2=4.517,P=0.034);家族性乳腺癌患者的雌激素受体(estrogen receptor,ER)表达阴性率(39.5%)高于散发性乳腺癌患者(25.4%),差异有统计学意义(X~2=3.977,P=0.046);Kaplan-Meier生存分析显示:家族性乳腺癌组3年无病生存率(disease free survival,DFS)为86.0%,而散发性组3年无病生存率为95.5%,差异有统计学意义(X~2=7.371,P=0.007)。但两组患者在年龄分布、民族、体质指数(body mass index,BMI)、绝经状态、肿瘤大小、病理类型、临床分期、腋窝淋巴结转移率、孕激素受体(progestrone receptor,PR)、人类表皮生长因子受体-2(human epidermal growth factor receptor-2,HER-2)、细胞核增殖抗原(cell nucleus generation antigen,Ki-67)表达以及乳腺癌分子分型方面差异均无统计学意义(均有P0.05)。结论广西地区家族性乳腺癌与散发性乳腺癌在一些临床病理特征上存在差异,可能提示预后不良。
[Abstract]:Objective to compare the clinicopathological characteristics of familial breast cancer and sporadic breast cancer, and to reveal the unique clinicopathological and molecular biological characteristics of familial breast cancer. Methods Clinical and pathological data of 445 female breast cancer patients treated in the first affiliated Hospital of Guangxi Medical University from January 2013 to January 2014 were analyzed retrospectively. 43 cases of familial breast cancer and 402 cases of sporadic breast cancer were analyzed. The clinicopathological characteristics, molecular biological behavior, recurrence and metastasis were compared between the two groups. Results in histological grade, the proportion of familial breast cancer patients divided into III grade (37.2g) was higher than that of sporadic breast cancer patients (22.6g%), the difference was statistically significant (P < 0.05); estrogen receptor (ER) expression in familial breast cancer patients was significantly higher than that in sporadic breast cancer patients (P < 0.05). The negative rate (39.5%) was higher than that in sporadic breast cancer patients (25.44%). The difference was statistically significant. Kaplan-Meier survival analysis showed that the 3-year disease-free survival rate of familial breast cancer group was 86.0 and that of sporadic group was 95.55.The difference was statistically significant. But in age distribution, nationality, body mass index (BMI) mass BMIA, menopausal status, tumor size, pathological type, clinical stage, axillary lymph node metastasis rate, There were no significant differences in the expression of progestrone receptor, human epidermal growth factor receptor -2human epidermal growth factor receptor-2hER-2and proliferating cell nucleus generation antigen-Ki-67 (all P 0.05). Conclusion there are some differences in clinicopathological features between familial breast cancer and sporadic breast cancer in Guangxi, which may indicate poor prognosis.
【作者单位】：广西医科大学第一附属医院胃肠腺体外科;合肥市第二人民医院内科;广西医科大学第一附属医院外科;
【基金】：广西医疗卫生适宜技术研究与开发课题资助项目(S201415-03)
【分类号】：R737.9

【相似文献】