EQ-5D-3L和FACT量表对北京癌症及癌前病变患者生活质量评估的信度和效度研究

发布时间：2018-07-01 12:31

本文选题：肿瘤 + 欧洲五维健康量表　；参考：《肿瘤》2017年09期

【摘要】：目的:本研究依托2013—2014年在北京市城市地区开展的食管癌、胃癌、结直肠癌、肝癌、肺癌和乳腺癌的人群筛查和早诊早治现场,采用欧洲五维健康量表EQ-5D-3L和癌症治疗功能评价量表(Functional Assessment of Cancer Therapy,FACT)对癌症及癌前病变患者的健康相关生活质量进行测量,并分析EQ-5D-3L和FACT针对北京市癌症人群的信度及效度。方法:采用EQ-5D-3L和FACT同时对1 001例癌症及癌前病变患者进行测量,对EQ-5D-3L及FACT的结果进行Cronbachα系数的内部一致性信度检验,对FACT采用公因子进行结构效度分析,对EQ-5D-3L和FACT进行对比以实现聚合效度的分析。结果 :对于肺癌、乳腺癌、结直肠癌、食管癌、肝癌和胃癌这6种癌症,EQ-5D-3L的Cronbachα系数分别为0.846、0.805、0.877、0.862、0.793和0.844,FACT的Cronbachα系数分别为0.935、0.916、0.950、0.952、0.915和0.953。在结构效度分析中,FACT累积解释方差分别为64.28%、65.15%、71.43%、67.21%、64.76%和70.56%。对比FACT,EQ-5D-3L的聚合效度分别为0.592、0.503、0.715、0.672、0.561和0.444,EQ-视觉模拟量表的聚合效度分别为0.553、0.606、0.576、0.579、0.361和0.364。结论 :EQ-5D-3L和FACT应用于北京市癌症及癌前病变患者的生活质量评估,具有较好的信度。FACT 6种癌症量表的结构效度较好,肺癌、乳腺癌、结直肠癌、肝癌和食管癌的EQ-5D-3L量表效度也较好,而胃癌及癌前病变的EQ-5D-3L量表效度一般。
[Abstract]:Objective: this study was based on screening and early diagnosis and treatment of esophageal cancer, gastric cancer, colorectal cancer, liver cancer, lung cancer and breast cancer in urban areas of Beijing from 2013 to 2014. EQ-5D-3L and functional Assessment of Cancer Therapeutics were used to measure the health-related quality of life in patients with cancer and precancerous lesions. The reliability and validity of EQ-5D-3L and fact for cancer patients in Beijing were analyzed. Methods: 1 001 patients with cancer and precancerous lesions were measured by EQ-5D-3L and fact. The results of EQ-5D-3L and fact were tested for the internal consistency reliability of Cronbach 伪 coefficients, and the structural validity of the common factors were analyzed. EQ-5 D-3 L and fact were compared to achieve the analysis of polymerization validity. Results: for lung cancer, breast cancer, colorectal cancer, esophageal cancer, liver cancer and gastric cancer, the Cronbach 伪 coefficients of EQ-5D-3L were 0.846 ~ 0.805 ~ (0.877) ~ 0.862 ~ 0.793 and 0.84 ~ (4) FACT, respectively. The Cronbach 伪 coefficients of six kinds of cancer were 0.9350.9160.9500.9520.915 and 0.95353 respectively. In the structural validity analysis, the variance of the cumulative interpretation of facts was 64.285.15 and 71.437.21, 64.76% and 70.5656%, respectively. Compared with facts EQ-5D-3L, the polymerization validity of the EQ-5D-3L was 0.592X 0.503U 0.7150.672U 0.561 and 0.444EQ- visual analogue scale 0.5530.6060.5760.5790.361 and 0.364 respectively. Conclusion the quality of life of patients with cancer and precancerous lesions in Beijing was evaluated by using the weight EQ-5D-3L and fact. The reliability of the six cancer scales was good. The structural validity of the six cancer scales was good, lung cancer, breast cancer, colorectal cancer, lung cancer, breast cancer and colorectal cancer. The validity of EQ-5D-3L scale for liver cancer and esophageal carcinoma was also good, while the validity of EQ-5D-3L scale for gastric cancer and precancerous lesions was moderate.
【作者单位】：中国医学科学院医学信息研究所公共卫生信息研究室;
【分类号】：R73-31

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