肺癌胰腺转移的临床特点及预后分析

发布时间：2018-07-20 15:30

【摘要】：背景与目的由于缺乏特异的临床症状,70%的肺癌患者确诊时为局部晚期或晚期,多数患者伴有实性器官转移,不同部位转移患者的临床表现及预后不同。随着诊断技术的发展,肺癌伴胰腺转移似有逐渐增多趋势。本研究针对肺癌胰腺转移的临床特点、诊治、预后及生存情况进行统计分析,探讨肺癌胰腺转移的相关预后因素。方法回顾性分析1996年7月-2017年6月于北京肿瘤医院胸部肿瘤内一科就诊的35例经病理确诊的肺癌并胰腺转移或在治疗过程中出现胰腺转移的患者,其中33例有完整随访资料。结果 35例患者中,小细胞肺癌28例(80%),腺癌3例(8.6%),鳞癌4例(11.4%)。初治时即存在胰腺转移者21例(60%),14例治疗过程中出现胰腺转移(40%)。在胰腺转移灶中,胰头转移者15例(42.9%),胰腺体尾部转移者20例(57.1%),单发转移23例(65.7%),多发转移12例(34.3%)。肺癌胰腺转移患者多无明显临床症状,本组病例中,仅4例患者在病程中出现胰腺炎症状。病理类型是影响肺癌胰腺转移患者生存的独立预后因素。结论部分晚期肺癌患者可以出现胰腺转移,多见于小细胞肺癌。肺癌患者出现胰腺转移,治疗原则以全身化疗为主的综合治疗。病理类型是影响肺癌胰腺转移患者生存的独立预后因素。
[Abstract]:Background and objective due to the absence of specific clinical symptoms 70% of lung cancer patients were locally advanced or advanced when diagnosed and most of the patients were accompanied with solid organ metastasis. The clinical manifestations and prognosis of patients with different sites of metastasis were different. With the development of diagnostic techniques, lung cancer with pancreatic metastasis seems to increase gradually. In this study, the clinical features, diagnosis and treatment, prognosis and survival of pancreatic metastasis of lung cancer were statistically analyzed, and the prognostic factors of pancreatic metastasis of lung cancer were discussed. Methods from July 1996 to June 2017, 35 cases of lung cancer with pancreatic metastasis or pancreatic metastasis were retrospectively analyzed. 33 of them had complete follow-up data. Results among the 35 patients, 28 (80%) were small cell lung cancer, 3 (8.6%) were adenocarcinoma, 4 (11.4%) were squamous cell carcinoma. Pancreatic metastasis was found in 21 cases (60%) and 14 cases (40%). There were 15 cases of pancreatic head metastasis (42.9%), 20 cases of pancreatic body and tail metastasis (57.1%), 23 cases of single metastasis (65.7%) and 12 cases of multiple metastasis (34.3%). There were no obvious clinical symptoms in patients with pancreatic metastasis of lung cancer, only 4 cases had pancreatitis symptoms in the course of the disease. Pathological type is an independent prognostic factor affecting the survival of patients with pancreatic metastasis from lung cancer. Conclusion Pancreatic metastasis can occur in some patients with advanced lung cancer, and is more common in small cell lung cancer. Lung cancer patients have pancreatic metastasis, the principle of treatment is systemic chemotherapy. Pathological type is an independent prognostic factor affecting the survival of patients with pancreatic metastasis from lung cancer.
【作者单位】：中国医学科学院肿瘤医院肿瘤内科;南平市人民医院肿瘤内科;北京大学临床肿瘤学院北京肿瘤医院胸部肿瘤内一科;
【分类号】：R734.2

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