SSTR2、Livin和Survivin在结肠癌组织中的表达及其意义
发布时间：2018-10-15 12:36
【摘要】：目的探讨生长抑素受体2(SSTR2),凋亡抑制因子Livin和存活素(Survivin)在结肠正常黏膜、结肠腺瘤、癌旁组织及结肠癌组织中的表达水平的变化规律及临床意义。方法采用逆转录聚合酶链反应(RT-PCR)方法检测收集到的30例结肠正常黏膜、30例结肠腺瘤、30例结肠癌旁组织、30例结肠癌组织中SSTR2、Livin和Survivin mRNA的表达情况,对其表达水平进行测定,分析不同组织表达阳性率及表达强度的差别。结果结肠癌标本中Livin和Survivin mRNA阳性表达率与结肠腺瘤比较明显升高,差异有统计学意义(P0.05)。而SSTR2mRNA的阳性表达率与结肠腺瘤比较明显降低,,差异有统计学意义(P0.05)。Livin和Survivin mRNA表达水平在结肠正常黏膜、结肠腺瘤、结肠瘤旁组织、结肠癌组织为逐渐增高趋势,而SSTR2mRNA为逐渐下降趋势。结论 SSTR2、Livin和Survivin在结肠黏膜从腺瘤到癌的转变过程中起着重要作用。
[Abstract]:Objective to investigate the expression of somatostatin receptor 2 (SSTR2), inhibitor of apoptosis (Livin) and survivin (Survivin) (survivin (Survivin) in normal colon mucosa, colon adenoma, paracancerous tissues and colon cancer tissues. Methods reverse transcriptase polymerase chain reaction (RT-PCR) was used to detect the expression of SSTR2,Livin and Survivin mRNA in 30 cases of normal colonic mucosa, 30 cases of colonic adenoma, 30 cases of paracancerous tissue and 30 cases of colon cancer. The positive rate and intensity of expression in different tissues were analyzed. Results the positive expression rate of Livin and Survivin mRNA in colon cancer was significantly higher than that in colon adenoma (P0.05). The positive expression rate of SSTR2mRNA was significantly lower than that of colon adenoma, and the difference was statistically significant (P0.05) the expression of). Livin and Survivin mRNA in normal colonic mucosa, colonic adenoma, colon cancer tissue were gradually increased. However, SSTR2mRNA decreased gradually. Conclusion SSTR2,Livin and Survivin play an important role in the transition of colon mucosa from adenoma to carcinoma.
【作者单位】： 湖南省长沙市第一医院消化内科;
【基金】：长沙市科技局计划项目(No:K1403059-31)
【分类号】：R735.35
[Abstract]:Objective to investigate the expression of somatostatin receptor 2 (SSTR2), inhibitor of apoptosis (Livin) and survivin (Survivin) (survivin (Survivin) in normal colon mucosa, colon adenoma, paracancerous tissues and colon cancer tissues. Methods reverse transcriptase polymerase chain reaction (RT-PCR) was used to detect the expression of SSTR2,Livin and Survivin mRNA in 30 cases of normal colonic mucosa, 30 cases of colonic adenoma, 30 cases of paracancerous tissue and 30 cases of colon cancer. The positive rate and intensity of expression in different tissues were analyzed. Results the positive expression rate of Livin and Survivin mRNA in colon cancer was significantly higher than that in colon adenoma (P0.05). The positive expression rate of SSTR2mRNA was significantly lower than that of colon adenoma, and the difference was statistically significant (P0.05) the expression of). Livin and Survivin mRNA in normal colonic mucosa, colonic adenoma, colon cancer tissue were gradually increased. However, SSTR2mRNA decreased gradually. Conclusion SSTR2,Livin and Survivin play an important role in the transition of colon mucosa from adenoma to carcinoma.
【作者单位】： 湖南省长沙市第一医院消化内科;
【基金】：长沙市科技局计划项目(No:K1403059-31)
【分类号】：R735.35
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