31例上皮样肉瘤的临床病例分析

发布时间：2018-11-26 09:04

【摘要】：目的:通过收集新疆医科大学附属肿瘤医院治疗的31例上皮样肉瘤的临床资料,分析上皮样肉瘤(ES)的临床特点、诊疗与预后的影响因素,为临床的诊疗提供依据。方法:对我院2010年1月至2015年12月间收治并获得随访31例上皮样肉瘤临床资料进行回顾性分析和生存分析,总结其临床特点,术前诊断,及术后复发的相关数据,以性别、年龄、肿瘤类型、肿瘤大小、有无放化疗、INI1表达情况为因素,进行复发因素的相关性分析。结果:本组6例患者死亡,5年总生存率78.8%。31例均获随访,随访时间为3-56个月,中位时间为27个月。5年复发率为70.9%,在单因素分析中,影响5年复发率的因素为肿瘤的类型及肿瘤大小,其中肿瘤5cm与≤5cm相比,肿瘤近端型与远端型相比,前者的5年复发率均高于后者(p0.05)。全组中CD34阳性表达占90.3%,INI1表达缺失占83.9%。对于肿瘤与周围血管神经界限不清的患者,给予术前放疗后可手术治疗,避免截肢。结论:上皮样肉瘤术前需要临床、影像学、病理学相结合,明确诊断及鉴别诊断,广泛切除仍是治疗的主要方式。INI1的表达缺失可以帮助ES的诊断及鉴别诊断,但不能提示预后,而肿瘤大小及肿瘤类型与预后有关。术前适行调强放疗可以缩小ES肿瘤大小,在局部晚期的患者中,可以避免截肢带来的不便,提高患者收益率。
[Abstract]:Objective: to collect the clinical data of 31 cases of epithelioid sarcoma treated in Cancer Hospital affiliated to Xinjiang Medical University, analyze the clinical characteristics, diagnosis, treatment and prognostic factors of Epidermoid sarcoma (ES), and provide the basis for clinical diagnosis and treatment. Methods: the clinical data of 31 cases of epithelioid sarcoma from January 2010 to December 2015 were retrospectively analyzed and analyzed. The clinical features, preoperative diagnosis and related data of recurrence were summarized. Age, tumor type, tumor size, radiotherapy and chemotherapy, INI1 expression were used as factors. Results: the 5-year overall survival rate of 78.8.31 cases was followed up for 3-56 months and the median time was 27 months. The 5-year recurrence rate was 70.9%. The factors influencing 5-year recurrence rate were tumor type and tumor size. The 5-year recurrence rate of tumor 5cm was higher than that of distal type compared with 鈮，

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