外周血端粒长度与非小细胞肺癌临床特征的相关性分析

发布时间：2019-01-16 06:39

【摘要】：目的:比较非小细胞肺癌患者与正常体检人群外周血相对端粒长度的差异,同时观察端粒长度与非小细胞肺癌临床特征的相关性。方法:选取2016年3月至2016年10月期间就诊于兰州军区兰州总医院,经肺部穿刺活检或气管镜下活检,病理结果显示为非小细胞肺癌(腺癌、鳞癌、大细胞癌等),共70例患者,并选取同期体检中心健康体检者40例作为对照组,检测非小细胞肺癌组及对照组外周血相对端粒长度的水平,同时统计非小细胞肺癌组的临床分期、病理类型、Ki-67阳性细胞数表达水平等,运用SPSS19.0统计学软件进行相关指标分析。结果:1.非小细胞肺癌组患者外周血相对端粒长度明显高于健康对照组(P0.05)。2.非小细胞肺癌组外周血相对端粒长度与临床分期相关,分期越晚(Ⅲ+Ⅳ),端粒长度缩小越明显(P0.05)。3.不同病理类型的非小细胞肺癌患者端粒长度不同,腺癌组较鳞癌组,端粒缩短更明显(P0.05)。4.外周血端粒长度受病灶大小的影响,病灶越大,端粒缩小越明显(P0.05)。5.非小细胞肺癌组中,淋巴结是否转移,端粒长度的变化无明显差异(P0.05)。6.非小细胞肺癌组中,是否已出现远处转移对端粒长度的变化无影响(P0.05)。7.非小细胞肺癌组中,不同Ki-67阳性细胞数表达水平与端粒长度有明显差异,Ki-67阳性细胞数表达水平越低,相对端粒长度越短(P0.05)。结论:1.非小细胞肺癌组的端粒长度较健康对照组明显缩短,有望成为非小细胞肺癌早期诊断的生物标志物之一;2.端粒长度与非小细胞肺癌的临床分期、病理类型、恶性程度密切相关,有望作为新的肿瘤标记物或药物治疗靶点。
[Abstract]:Objective: to compare the relative telomere length in peripheral blood between patients with non-small cell lung cancer (NSCLC) and normal controls, and to observe the correlation between telomere length and clinical features of NSCLC. Methods: 70 patients with non-small cell lung cancer (adenocarcinoma, squamous cell carcinoma, large cell carcinoma, etc.) were selected from Lanzhou General Hospital of Lanzhou military region from March 2016 to October 2016. The relative telomere length of peripheral blood in non-small cell lung cancer (NSCLC) group and control group were measured, and the clinical stages and pathological types of NSCLC group were analyzed. The expression level of Ki-67 positive cells was analyzed by SPSS19.0 software. Results: 1. The relative telomere length of peripheral blood in non-small cell lung cancer group was significantly higher than that in healthy control group (P0.05). In non-small cell lung cancer group, the relative telomere length in peripheral blood was correlated with clinical stage. The later the stage (鈪，

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