恶性肿瘤患者医院获得性屎肠球菌血流感染临床特点与死亡危险因素分析
发布时间：2019-03-20 08:54
【摘要】：目的探讨恶性肿瘤合并医院获得性屎肠球菌血流感染患者的临床特点及其死亡危险因素。方法回顾性收集2012年1月-2015年12月恶性肿瘤合并医院获得性屎肠球菌血流感染93例患者的临床资料,采用logistic回归分析死亡危险因素。结果 93例患者中肿瘤类型为实体肿瘤82例占88.17%;伴有发热患者86例占92.47%,伴有寒颤患者56例占60.22%;白细胞计数和(或)中性粒细胞计数升高84例占90.32%,C-反应蛋白(CRP)升高89例占95.70%;继发性血流感染61例占65.59%;药敏数据显示,对万古霉素的耐药率为5.63%,无替考拉宁和利奈唑胺耐药菌株;30天病死率为26.88%;单因素分析显示入住ICU、肾功能不全、查尔森合并指数(CCI)、急性生理慢性健康评分(APACHEⅡ)、继发血流感染、发病前30天内行外科手术、化疗、机械通气、气管插管/切开和留置尿管与死亡相关(P0.05);多因素logistic回归分析显示仅APACHE II评分与死亡相关(P0.001)。结论恶性肿瘤合并医院获得性屎肠球菌血流感染患者的临床特点主要有发热、寒颤、白细胞和(或)中性粒细胞升高、CRP升高;屎肠球菌分离株对万古霉素、替考拉宁和利奈唑胺均敏感;高APACHEⅡ评分是死亡的独立危险因素。
[Abstract]:Objective to investigate the clinical features and risk factors of death in patients with malignant tumor complicated with nosocomial enterococcus faecium blood flow infection. Methods the clinical data of 93 patients with malignant tumor complicated with hospital acquired enterococcus faecium blood flow infection from January 2012 to December 2015 were retrospectively collected. The risk factors of death were analyzed by logistic regression. Results of the 93 cases, 82 cases were solid tumors (88.17%), 86 cases with fever (92.47%), 56 cases with shivering (60.22%), 86 cases with fever (92.47%) and 56 cases with shivering (60.22%). Leukocyte count and / or neutrophil count increased in 84 cases (90.32%), C-reactive protein (CRP) increased in 89 cases (95.70%), secondary blood flow infection in 61 cases (65.59%). The drug sensitivity data showed that the resistance rate to vancomycin was 5.63%, no teicoplanin and linazolamine resistant strains were found, the 30-day mortality rate was 26.88%, and the resistance rate to vancomycin was 5.63%. Univariate analysis showed renal insufficiency in ICU, (CCI), acute physiological and chronic health score (APACHE 鈪，
本文编号：2444053
[Abstract]:Objective to investigate the clinical features and risk factors of death in patients with malignant tumor complicated with nosocomial enterococcus faecium blood flow infection. Methods the clinical data of 93 patients with malignant tumor complicated with hospital acquired enterococcus faecium blood flow infection from January 2012 to December 2015 were retrospectively collected. The risk factors of death were analyzed by logistic regression. Results of the 93 cases, 82 cases were solid tumors (88.17%), 86 cases with fever (92.47%), 56 cases with shivering (60.22%), 86 cases with fever (92.47%) and 56 cases with shivering (60.22%). Leukocyte count and / or neutrophil count increased in 84 cases (90.32%), C-reactive protein (CRP) increased in 89 cases (95.70%), secondary blood flow infection in 61 cases (65.59%). The drug sensitivity data showed that the resistance rate to vancomycin was 5.63%, no teicoplanin and linazolamine resistant strains were found, the 30-day mortality rate was 26.88%, and the resistance rate to vancomycin was 5.63%. Univariate analysis showed renal insufficiency in ICU, (CCI), acute physiological and chronic health score (APACHE 鈪，
本文编号：2444053
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