肺癌化疗中铂类耐药的研究进展
发布时间：2019-08-09 15:58
【摘要】：铂类化疗药物是治疗多种恶性肿瘤的基础用药,在非小细胞肺癌中,铂类联合其他药物仍是治疗的主要方案,早期效果显著。随着疗程进展,肿瘤细胞对化疗药物产生耐药是影响疗效和预后的重要因素,其耐药机制复杂,如膜蛋白表达异常、DNA修复功能增强、凋亡调控机制异常、细胞解毒功能增强等。本文总结了肺癌细胞铂类耐药的一些主要机制,以期帮助开发新的靶点类似物或抑制剂,与铂类药物联合使用提高疗效。
[Abstract]:Platinum chemotherapeutic drugs are the basic drugs for the treatment of many kinds of malignant tumors. Platinum combined with other drugs is still the main treatment scheme in non-small cell lung cancer, and the early effect is remarkable. With the progress of the course of treatment, the drug resistance of tumor cells to chemotherapeutic drugs is an important factor affecting the curative effect and prognosis, and its drug resistance mechanism is complex, such as abnormal expression of membrane protein, enhanced DNA repair function, abnormal apoptosis regulation mechanism, enhanced cell detoxification function and so on. In this paper, some main mechanisms of platinum resistance in lung cancer cells were summarized in order to help develop new target analogues or inhibitors and combine with platinum drugs to improve the curative effect.
【作者单位】： 中国人民武装警察部队总医院呼吸内科;锦州医科大学临床医学系;
【基金】：国家自然科学基金(81402471) 北京市科技新星计划(2017008) 武警总医院培育项目(WZ201406)~~
【分类号】：R734.2
[Abstract]:Platinum chemotherapeutic drugs are the basic drugs for the treatment of many kinds of malignant tumors. Platinum combined with other drugs is still the main treatment scheme in non-small cell lung cancer, and the early effect is remarkable. With the progress of the course of treatment, the drug resistance of tumor cells to chemotherapeutic drugs is an important factor affecting the curative effect and prognosis, and its drug resistance mechanism is complex, such as abnormal expression of membrane protein, enhanced DNA repair function, abnormal apoptosis regulation mechanism, enhanced cell detoxification function and so on. In this paper, some main mechanisms of platinum resistance in lung cancer cells were summarized in order to help develop new target analogues or inhibitors and combine with platinum drugs to improve the curative effect.
【作者单位】： 中国人民武装警察部队总医院呼吸内科;锦州医科大学临床医学系;
【基金】：国家自然科学基金(81402471) 北京市科技新星计划(2017008) 武警总医院培育项目(WZ201406)~~
【分类号】：R734.2
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