瘀血对过敏性紫癜患儿肾脏损伤的影响

发布时间：2017-12-28 11:22

本文关键词：瘀血对过敏性紫癜患儿肾脏损伤的影响　出处：《中华中医药杂志》2017年08期 　论文类型：期刊论文

【摘要】：目的:通过对过敏性紫癜(HSP)与紫癜性肾炎(HSPN)患儿瘀血积分、凝血相关指标的观察,探讨瘀血对HSP患儿肾脏损伤的影响。方法:85例患儿按有无尿检异常分为HSP组45例,HSPN组40例。根据中医瘀血症候积分表进行瘀血评分。采用免疫比浊法测D-二聚体(D-Dimer),ELISA法测血浆与尿液纤溶酶原激活物抑制剂-1(PAI-1)。结果:与HSP组比较,HSPN组瘀血积分、尿PAI-1/Cr明显增高(P0.05)。血D-Dimer、血PAI-1在HSP和HSPN组差异无统计学意义。尿PAI-1/Cr与瘀血积分、24h尿蛋白定量均呈正相关(P0.05)。结论:瘀血参与了HSP患儿肾脏损伤的发生,尿液中PAI-1水平的增高与HSP肾脏损伤有关。
[Abstract]:Objective: To explore the effect of blood stasis on renal injury in children with HSP, through observing the blood stasis and blood coagulation related indexes in children with Henoch Schonlein purpura (HSP) and purpura nephritis (HSPN). Methods: 85 cases according to whether the abnormal urine into HSP 45 cases, HSPN group of 40 cases. The blood stasis score was carried out according to the syndrome of blood stasis syndrome in Chinese medicine. D- two polymer (D-Dimer) was measured by immuno turbidimetry, and plasma and urine plasminogen activator inhibitor -1 (PAI-1) was measured by ELISA. Results: compared with the HSP group, the blood stasis score and the urinary PAI-1/Cr in the HSPN group were significantly higher (P0.05). There was no significant difference between the blood D-Dimer and the blood PAI-1 in the group of HSP and HSPN. The urine PAI-1/Cr was positively correlated with the blood stasis integral and the quantitative 24h urine protein (P0.05). Conclusion: blood stasis is involved in the occurrence of renal injury in children with HSP, and the increase of PAI-1 in urine is related to the renal injury of HSP.
【作者单位】：河南中医药大学;河南中医药大学第一附属医院儿科;
【基金】：2012年河南省高校科技创新人才支持计划(No.2012HASTIT019) 2014年河南省科技创新杰出青年科技计划(No.144100510014)~~
【分类号】：R272
【正文快照】： 过敏性紫癜(Henoch-Sch?nlein purpura,HSP)是以小血管炎病变为基础的全身性血管炎综合征。临床表现主要为非血小板减少性可触性皮肤紫癜,常伴腹痛、关节痛,20%-60%的HSP患儿易发生肾脏损伤,出现血尿、蛋白尿等症状,即紫癜性肾炎(Henoch-Sch?nlein purpura nephritis,HSPN)[1]

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