颈部推拿对兔颈动脉粥样硬化重度狭窄病变的血管拉伸力学特性的影响

发布时间：2018-01-03 12:19

本文关键词：颈部推拿对兔颈动脉粥样硬化重度狭窄病变的血管拉伸力学特性的影响　出处：《中国临床解剖学杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的探讨颈部推拿手法对兔颈动脉粥样硬化(CAS)重度狭窄的血管拉伸力学特性的影响。方法 45只新西兰兔随机分为颈椎旋转组(n=12)、推桥弓组(n=12)、模型对照组(n=12)和空白对照组(n=9),在颈椎旋转组、推桥弓组和模型对照组建立左侧CAS模型,并分别接受颈椎旋转手法、推桥弓手法干预3周,模型对照组和空白对照组不作手法干预。取左侧颈动脉进行单轴拉伸试验和病理观察,比较四组兔颈动脉的拉伸力学特性。结果 (1)26只兔造模成功,其中颈椎旋转组、推桥弓组、模型对照组兔颈动脉的最大载荷显著高于空白对照组,同时最大应变显著低于空白对照组(P0.05);(2)颈椎旋转组兔颈动脉的弹性模量显著高于模型对照组、推桥弓组和空白对照组(P0.05),而推桥弓组兔颈动脉的弹性模量与模型对照组相比差异无统计学意义(P0.05)。结论动脉粥样硬化病变可致兔颈动脉血管拉伸力学特性下降,而颈部旋转推拿治疗可导致严重粥样硬化病变并重度狭窄的兔颈动脉弹性下降,为临床安全应用颈部推拿手法提供了参考。
[Abstract]:Objective to investigate the effect of cervical massage manipulation on the tensile mechanical properties of severe stenosis of carotid atherosclerosis in rabbits. Methods 45 New Zealand rabbits were randomly divided into cervical spine rotation group (n = 12). The left CAS model was established in the cervical spine rotation group, the push bridge arch group and the model control group. The left carotid artery was taken for uniaxial tension test and pathological observation. Results the tensile mechanical properties of the carotid artery in the four groups were compared. Results 26 rabbits were successfully modeled. The maximum load of carotid artery in the cervical spine rotation group, the bridge arch group and the model control group was significantly higher than that in the blank control group. At the same time, the maximum strain was significantly lower than that of the blank control group (P 0.05). (2) the elastic modulus of carotid artery in the cervical spine rotation group was significantly higher than that in the model control group (P 0.05). Compared with the model control group, there was no significant difference in the elastic modulus of carotid artery between the two groups (P 0.05). Conclusion Atherosclerosis can cause the decrease of tensile mechanical properties of carotid artery in rabbits. The cervical rotation massage treatment can lead to severe atherosclerotic lesions and severe stenosis of rabbit carotid artery elasticity decline, which provides a reference for clinical safe application of cervical massage manipulation.
【作者单位】：南方医科大学中医药学院;广州中医药大学;西南医科大学附属中医医院;
【基金】：国家自然科学基金资助项目(81273871) 四川省教育厅科研项目(17ZB0472) 泸州市科技局科技计划项目(2016-176-13)
【分类号】：R244.1
【正文快照】： 颈部推拿治疗因具有良好的临床疗效而被广泛应用于颈椎疾病的治疗和康复。不过,颈椎结构较脊柱其他部分相对薄弱,稳定性差,颈动脉等重要结构位置表浅,易受颈部推拿作用力的影响而损伤,临床上也有颈部推拿致一过性低血压、眩晕发作、颈椎骨折、脑卒中甚至死亡的报道。相较于

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