十味柴赭汤治疗功能性消化不良（肝胃不和型）的临床观察

发布时间：2018-01-03 19:01

本文关键词：十味柴赭汤治疗功能性消化不良（肝胃不和型）的临床观察　出处：《河南中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:通过观察改善的中医症状积分、临床安全方面、以及不良反应的发生率、复发率等情况,综合评估十味柴赭汤的临床治疗疗效及安全有效性,并试从理论和临床研究两个方面探索其作用机理,从而为中医药在治疗肝胃不和型消化不良的道路上提供理论依据。方法:选取符合标准的患者,随机分组。在研究进行过程中,两组病例除了给予基础治疗之外,治疗组给予十味柴赭汤治疗,所服用的中药由河南省中医院统一购置,煎煮成200ml袋装汤剂,每次1袋,每日早、晚口服。对照组给予枸橼酸莫沙必利胶囊口服,每次5 mg,日3次,饭前服用。两组均观察4周。治疗结束12周后进行随访,观察服药前后指标变化,并对指标进行统计学处理。结果:根据临床观察结果显示:1.本研究所纳入的病例共72例,然研究过程中脱落12例,结束后两组各观察30例,两组患者在治疗前对年龄、病程、性别等方面进行统计学的处理,结果无显著性差异(P0.05),其具有可比性;2.治疗后的总体疗效比较:治疗组总有效率90%,明显优于对照组总有效率76.67%,两组疗效差异经统计学分析,有显著性统计学意义(P0.05),这表明十味柴赭汤治疗功能性消化不良(肝胃不和型)患者的临床疗效明显优于枸橼酸莫沙必利胶囊。3.治疗组在改善患者胃脘或脘腹胀满、胸胁胀闷或胀痛、食欲不振、恶心呕吐、嗳气、大便不爽等方面的疗效明显优于对照组,但两组在改善善太息症状上疗效相当,无明显差异,没有统计学意义。4.治疗疗程结束后12周进行随访,治疗组的复发率明显低于对照组,说明十味柴赭汤在治疗功能性消化不良的远期疗效方面更有优势。结论:十味柴赭汤是治疗(肝胃不和型)功能性消化不良的有效方剂,能明显改善患者临床症状,降低复发率,安全可靠,值得临床广泛推广。
[Abstract]:Objective: to evaluate the clinical efficacy and safety of Shiwei Zhe decoction by observing the symptom score, clinical safety, the incidence of adverse reactions and the recurrence rate of Shiwei Zhe decoction. And from two aspects of theoretical and clinical research to explore its mechanism, so as to provide a theoretical basis for Chinese medicine in the treatment of hepatogastric disharmony dyspepsia. In the course of the study, the two groups of cases were treated with Shiwei Chaizhe decoction in addition to basic treatment, and the traditional Chinese medicine was purchased by Henan Hospital of traditional Chinese Medicine. The decoction was made into 200ml pouch decoction, 1 bag per day, early and late oral, while the control group was given oral mosapride citrate capsule, 5 mg, 3 times a day. Both groups were observed for 4 weeks. 12 weeks after treatment were followed up to observe the changes of indexes before and after treatment. Results: according to the clinical observation results, there were 72 cases included in this study, but 12 cases were lost in the course of the study, and 30 cases were observed in each group after the end of the study. The two groups of patients before the treatment of age, course of disease, sex and other aspects of statistical processing, the results were no significant difference (P 0.05), it is comparable; 2. Comparison of the overall efficacy after treatment: the total effective rate of the treatment group was 90, significantly better than the total effective rate of the control group 76.67. The difference between the two groups was statistically analyzed. There was significant statistical significance (P0.05). This indicates that the clinical efficacy of Shiwei Chaizhe decoction in treating patients with functional dyspepsia (liver-stomach disharmony type) is obviously better than that of mosapride citrate capsule .3.The treatment group can improve the stomachache or abdominal distention in patients. Chest and flank distension or distension pain, loss of appetite, nausea and vomiting, belching, stool upset and other aspects of the curative effect was significantly better than the control group, but the two groups in improving the symptoms of good too much, there is no significant difference. No statistical significance. 4. 12 weeks after the end of treatment, the recurrence rate in the treatment group was significantly lower than that in the control group. Conclusion: Shiwei Chai Zhe decoction is an effective prescription for the treatment of functional dyspepsia. It can obviously improve the clinical symptoms, reduce the recurrence rate, and is safe and reliable.
【学位授予单位】：河南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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