血府逐瘀汤对老年冠心病合并抑郁症患者血清炎性因子水平的影响

发布时间：2018-01-09 04:01

本文关键词：血府逐瘀汤对老年冠心病合并抑郁症患者血清炎性因子水平的影响　出处：《辽宁中医杂志》2017年09期 　论文类型：期刊论文

【摘要】：目的:观察血府逐瘀汤对老年冠心病合并抑郁症患者血清炎性因子水平的影响。方法:选择2015年2月—2016年2月110例在该院确诊治疗的老年冠心病合并抑郁症患者,均分为两组,对照组服用辛伐他汀分散片治疗;观察组采用血府逐瘀汤治疗。测定患者血清TNF-α、CRP、IL-8的含量。用汉密尔顿抑郁量表(HAMD)评分法及SDS评分对两组患者治疗前后抑郁情况进行评分比较;用西雅图心绞痛调查量表(SAQ)对患者生活质量进行评分比较。随访记录患者心血管不良事件的发生情况。结果:治疗后观察组患者SAQ评分显著高于对照组(P0.05);SDS、HAMD评分显著低于对照组(P0.05);两组经治疗后TNF-α、CRP、IL-8水平明显降低(P0.05),观察组明显低于对照组(P0.05);观察组心血管不良事件发生率(3.64%)明显少于对照组(25.45%)(P0.05)。结论:血府逐瘀汤能有效降低老年冠心病合并抑郁症患者炎性因子水平,改善患者抑郁状况及生活质量,降低不良心血管事件发生率。
[Abstract]:Objective: to observe the effect of Xuefu Zhuyu decoction on serum inflammatory factors in elderly patients with coronary heart disease and depression. From February 2015 to February 2016, 110 elderly patients with coronary heart disease complicated with depression were selected. All patients were divided into two groups. The control group was treated with simvastatin dispersible tablets. The patients in the observation group were treated with Xuefu Zhuyu decoction and the serum TNF- 伪 -CRP was measured. The content of IL-8. The scores of depression before and after treatment were compared by Hamilton Depression scale (Hamd) and SDS. Using the Seattle angina Survey scale (SAQ). Results: the SAQ score of patients in the observation group after treatment was significantly higher than that in the control group (P 0.05). The score of SDSm Hamd was significantly lower than that of control group (P 0.05). After treatment, the level of IL-8 in TNF- 伪 CRPnC was significantly decreased in the two groups, and the level of IL-8 in the observation group was significantly lower than that in the control group (P 0.05). The incidence of cardiovascular adverse events in the observation group was significantly lower than that in the control group (P 0.05). Conclusion: Xuefu Zhuyu decoction can effectively reduce the level of inflammatory factors in elderly patients with coronary heart disease and depression. To improve the depression and quality of life, reduce the incidence of adverse cardiovascular events.
【作者单位】：南阳医学高等专科学校中医系;
【分类号】：R259;R277.7
【正文快照】： 冠心病患者除了受到临床躯体症状困扰的同时,往往还会出现不同程度的抑郁、焦虑等不良情绪[1]。反复无常的病痛和沉重的经济负担都会给患者造成极大的心理压力,进而演变为抑郁症等不良心理疾病[2]。冠心病合并抑郁症对老年患者的生活质量和预后都会造成不良的影响,但临床往往

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