电针与手针刺激对围绝经期烘热症状及性激素水平影响的对比分析

发布时间：2018-01-09 18:34

本文关键词：电针与手针刺激对围绝经期烘热症状及性激素水平影响的对比分析　出处：《湖南中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:本研究以围绝经期综合征患者为观察对象,分别以手针刺激与电针刺激作为治疗手段,评价手针刺激和电针刺激对围绝经期综合征烘热及相关症状的疗效对比;同时比较手针刺激和电针刺激对围绝经期综合征患者性激素水平的影响,为针灸刺治疗围绝经期综合征的研究提供一定的临床证据。方法:将50例围绝经期综合征患者随机分为手针组和电针组,脱落1例,有效病例49例,手针组27例,电针组22例。两组均采用疏密波,频率为10/50Hz,刺激30分钟。两组治疗均隔日一次,每周3次,连续8周,共治疗24次。研究于入组时、入组后第4、8、20、32周分别记录患者的烘热积分、绝经症状评价量表评分(MRS)、围绝经期生活质量量表评分(MENQOL),于入组时、入组后第8、20周检查患者的血清性激素水平(FSH、LH、E2),并对数据进行统计与分析。结果:1.烘热积分、MRS、MENQOL评分:与治疗前比:两组治疗4周、8周及20周、32周随访,三者评分均有减少,差异有统计学意义(p0.05),说明两组治疗均能改善围绝经期患者烘热及相关症状。与治疗4周比:治疗8周三者评分仍有降低,差异有统计学意义(p0.05),说明随着治疗周期的延长,患者烘热及相关症状进一步改善。与治疗8周时比:20周、32周的随访三者疗效比较差异有统计学意义(p0.05),且与第20周随访时比:第32周随访MENQOL评分比较差异有统计学意义(p0.05),说明两组在随访期随着时间的推移,仍能进一步改善患者的烘热及相关症状。2.血清性激素水平:与治疗前比,两组内各时间点LH值稍有降低,但差异无统计学意义(p0.05);两组治疗8周及第20周随访较治疗前FSH水平均有降低,差异有统计学意义(p0.05),但与治疗第8周时比,第20周随访FSH值虽有降低,但差异无统计学意义(p0.05);两组治疗8周及第20周随访较治疗前E2值有所提高,差异有统计学意义(p0.05),但与治疗第8周时比,入组后20周随访E2值虽有升高,但差异无统计学意义(p0.05)。说明两组治疗均未能显著影响患者的LH水平,但治疗8周已有效调节患者FSH及E2水平,并维持到入组后20周。3.两组间烘热积分、MRS、MENQOL评分、血清FSH、LH、E2值比差异均无统计学意义(p0.05),该结果有待扩大样本含量进一步验证。结论:1.手针与电针对围绝经期烘热及相关症状均有改善作用,且有较好的远期疗效。2.手针、电针对围绝经期综合征患者血清性激素均有一定的调节作用。3.手针、电针对围绝经期综合征疗效无明显差别,该结论有待进一步研究。
[Abstract]:Objective: to observe the patients with peri-menopausal syndrome and treat them with hand acupuncture and electroacupuncture respectively. To evaluate the efficacy of hand acupuncture stimulation and electroacupuncture stimulation in the treatment of peri-menopausal syndrome fever and related symptoms. At the same time, the effects of hand acupuncture stimulation and electroacupuncture stimulation on the sex hormone levels in patients with peri-menopausal syndrome were compared. Methods: 50 patients with peri-menopausal syndrome were randomly divided into hand acupuncture group and electroacupuncture group. 27 cases in the hand acupuncture group and 22 cases in the electroacupuncture group. The two groups were treated with 10 / 50 Hz stimulation for 30 minutes. The two groups were treated once every other day, 3 times a week for 8 weeks. A total of 24 times were treated. At the time of entering the group, the dry heat score and the menopausal symptom evaluation scale (MRS) were recorded respectively at the 4th week, 20th week, 20th week after entering the group. The quality of life scale (QOL) in the menopausal period was evaluated by MENQOLA, and the serum sex hormone level of the patients was examined at 8th week after entering the group and FSHLHHU E2). The data were analyzed and statistically analyzed. Results: the score of roasting heat score and MRSMENQOL score: compared with before treatment: the two groups were followed up for 4 weeks, 8 weeks and 20 weeks and 32 weeks, respectively. The scores of the three groups were all decreased. The difference was statistically significant (P 0.05), which indicated that both groups could improve the drying fever and related symptoms of perimenopausal patients. The difference was statistically significant (P 0.05), indicating that the baking heat and related symptoms improved further with the prolongation of the treatment cycle, compared with that at 8 weeks after treatment for 20 weeks. The results of 32 weeks follow-up showed significant difference among the three groups (p 0.05). And compared with the 20th week follow-up: the 32 week follow-up MENQOL score difference was statistically significant, indicating that the two groups in the follow-up period with the passage of time. The level of serum sex hormone: compared with before treatment, the LH value of the two groups decreased slightly at each time point, but the difference was not statistically significant (P 0.05). The FSH level of the two groups was significantly lower than that of the control group at 8 and 20 weeks, the difference was statistically significant (p 0.05), but compared with that at the 8th week, the FSH value of the follow-up at the 20th week was lower than that of the control group. But the difference was not statistically significant (P 0.05). The E _ 2 values of the two groups at 8 and 20 weeks were higher than those before treatment, and the difference was statistically significant (p 0.05). However, compared with the 8th week of treatment, the E _ 2 values of the 20 weeks follow up were higher than those of the control group. However, the difference was not statistically significant (P 0.05). It showed that the two groups of treatment did not significantly affect the level of LH, but after 8 weeks of treatment, the levels of FSH and E2 were effectively regulated. The results showed that there was no significant difference between the two groups in the score of roasting heat and the score of MRSMA MENQOL and the ratio of serum FSHN LHN E 2 between the two groups (P 0.05). The results need to be further verified by expanding the sample size. Conclusion 1. Both hand acupuncture and electroacupuncture can improve peri menopausal fever and related symptoms, and have a good long-term effect. 2. Hand acupuncture. Electroacupuncture has certain regulating effect on serum sex hormone in patients with perimenopausal syndrome .3.The curative effect of hand acupuncture and electroacupuncture on perimenopausal syndrome has no significant difference. This conclusion needs further study.
【学位授予单位】：湖南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R246.3

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