益坤抗衰汤联合克龄蒙治疗肾虚型卵巢早衰的临床观察

发布时间：2018-01-19 03:04

本文关键词： 卵巢早衰益坤抗衰汤克龄蒙肾虚临床研究　出处：《山西省中医药研究院》2017年硕士论文　论文类型：学位论文

【摘要】：目的观察张晋峰教授经验方益坤抗衰汤联合克龄蒙治疗肾虚型卵巢早衰的临床疗效并初步探讨其作用机理。方法严格按照纳入标准及排除标准,门诊收集60例符合入选标准的肾虚型卵巢早衰患者,随机分为三组,治疗组为益坤抗衰汤联合克龄蒙组,简称益克联合组;中药对照组为益坤抗衰组;西药对照组为克龄组。益克联合组服用益坤抗衰汤联合克龄蒙;益坤抗衰组服用益坤抗衰汤;克龄组服用克龄蒙。治疗周期均为3个月,治疗结束后均再观察3个月。观察治疗前后的疾病综合疗效、中医证候疗效、中医证候总积分变化情况、月经不调积分改善情况、中医主症腰膝酸软积分变化情况、FSH值、LH值、E2值变化情况、子宫内膜厚度及左右卵巢大小变化情况。并注意血常规、尿常规、凝血常规、肝肾功能、心电图、子宫及双侧附件彩超、双侧乳腺彩超等安全性等观测。所有数据均采用SPSS16.0软件进行统计学分析,并依据统计结果,做出结论。结果益克联合组治疗肾虚型卵巢早衰总有效率为89.47%,中医证候疗效有效率94.73%。治疗后患者FSH值、LH值较治疗前均显著下降(P0.01;P0.01)、E2值较治疗前显著升高(P0.01);子宫内膜厚度较治疗前也有显著增厚(P0.01);月经不调积分、腰膝酸软积分及中医证候总积分均有显著下降(P0.01)。结论益坤抗衰汤联合克龄蒙治疗肾虚型卵巢早衰有确切的临床疗效,可以有效地改善肾虚型卵巢早衰患者的月经不调情况、改善中医证候积分、减轻腰膝酸软的症状、降低FSH值、LH值,升高E2值、增加子宫内膜厚度。益克联合组疗效明显优于克龄组及益坤抗衰组。益坤抗衰汤联合克龄蒙治疗肾虚型卵巢早衰疗效确切,安全性好,值得临床进一步研究与推广。
[Abstract]:Objective to observe the clinical effect of Professor Zhang Jinfeng's experience prescription Yikun Kangshuai decoction combined with Kelingmeng in the treatment of premature ovarian failure of kidney deficiency type and to explore its mechanism. Methods according to the inclusive standard and exclusion standard strictly. Sixty patients with premature ovarian failure of kidney deficiency type were randomly divided into three groups. The treatment group was treated with Yikun Kangshuai decoction combined with Ke Ling Meng group. The traditional Chinese medicine control group: Yikun anti-aging group; The western medicine control group was Keling group, Yike combination group was treated with Yikun Kangshuai decoction combined with Kelingmen; Yikun Kangshuai group took Yikun Kangshuai decoction; The treatment period of Keling group was 3 months and the treatment period was 3 months. The comprehensive curative effect of the disease before and after treatment the curative effect of TCM syndromes and the change of total integral of TCM syndrome were observed before and after the treatment. Improvement of menstrual irregular score, changes of Lumbar and knee acid and soft score in TCM, changes of FSH value and LH value and E2 value, endometrial thickness and size of left and right ovaries, and pay attention to blood routine. Urine routine, coagulation routine, liver and kidney function, electrocardiogram, uterus and bilateral accessory color ultrasound, bilateral breast color ultrasound and other safety observation. All data were statistically analyzed by SPSS16.0 software. Results the total effective rate of treatment of kidney deficiency type premature ovarian failure was 89.47, and the effective rate of TCM syndromes was 94.73. The FSH value of patients after treatment was obtained. The value of LH was significantly lower than that before treatment (P 0.01). The E _ 2 value of P _ (0.01) was significantly higher than that before treatment. The thickness of endometrium was significantly thicker than that before treatment. Menstrual disorder score, waist and knee acid-soft score and total integral of TCM syndromes were significantly decreased P0.01.Conclusion Yikun Kangshuai decoction combined with Kelingmeng has definite clinical curative effect on premature ovarian failure of kidney deficiency type. Can effectively improve the kidney deficiency type of premature ovarian failure patients menstrual disorder, improve the TCM syndrome score, reduce the waist and knee pain and soft symptoms, reduce the FSH value of LH, increase E2 value. Increase the thickness of endometrium. Yike combination group is significantly better than the Ke Ling group and Yikun anti-aging group. Yikun Kangshuai decoction combined with Ke Ling Meng treatment of kidney deficiency type of premature ovarian failure is effective and safe. It is worthy of further clinical research and promotion.
【学位授予单位】：山西省中医药研究院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R271.9

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